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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Cytokines in the stools of children with complicated shigellosis.
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Cytokines in the stools of children with complicated shigellosis.

机译：复杂志贺氏菌病患儿粪便中的细胞因子。

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The pathogenesis of the systemic complications, leukemoid reaction and hemolytic uremic syndrome, associated with Shigella dysenteriae type 1 infection is not well understood. The excessive production of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), has been suggested as a possible factor. We measured IL-6 and TNF-alpha in stools of 56 children with S. dysenteriae 1 infection and 29 children without any apparent infection, all age 12 to 60 months. Sixteen children with S. dysenteriae 1 infection had leukemoid reaction or hemolytic uremic syndrome (complicated shigellosis), while the others did not (uncomplicated shigellosis). Stool IL-6 and TNF-alpha concentrations were higher in children with uncomplicated shigellosis than in children with complicated shigellosis (P = 0.009 and < 0.001, respectively) or in uninfected children (P < 0.001). It is concluded that complicated infection is not associated with higher concentrations of the proinflammatory cytokines IL-6 and TNF-alpha in stool.
机译：与痢疾志贺氏菌1型感染有关的全身并发症，类白血病反应和溶血性尿毒症综合征的发病机理尚不清楚。促肿瘤细胞因子包括肿瘤坏死因子α（TNF-alpha）和白介素6（IL-6）的过量产生是可能的因素。我们对年龄在12至60个月的56例痢疾链球菌1感染儿童和29例无明显感染的儿童的粪便中测量了IL-6和TNF-α。痢疾链球菌1型感染的16例儿童患有类白血病反应或溶血性尿毒症综合征（并发志贺氏菌病），而其他则没有（未并发志贺氏菌病）。单纯性志贺氏菌病患儿的粪便IL-6和TNF-α浓度高于复杂性志贺氏菌病患儿（分别为P = 0.009和<0.001）或未感染的患儿（P <0.001）。结论是复杂的感染与粪便中较高浓度的促炎细胞因子IL-6和TNF-α无关。

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