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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Angiotensin II Increases Host Resistance to Peritonitis
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Angiotensin II Increases Host Resistance to Peritonitis

机译：血管紧张素II增加宿主对腹膜炎的抵抗力

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Studies by other laboratories have shown that angiotensin II (AII) can affect the function of cells which comprise the immune system. In the present study, the effect of AII on the function of peritoneal macrophages and peripheral blood monocytes was assessed. In vitro exposure (4 h prior to assay) of peritoneal macrophages from mice and rats to AII increased the percentage of cells that phagocytosed opsonized yeast and the number of yeast per macrophage. Furthermore, AII increased the respiratory burst capacity of peritoneal macrophages from mice and rats and peripheral blood mononuclear cells from humans. Because of these observations, the effect of AII on host resistance to bacterial infection was assessed. Intraperitoneal administration of AII was shown to increase host resistance (reduced abscess formation) in an animal model of bacterial peritonitis. Studies were then conducted to assess whether parenteral administration of AII, a clinically relevant route, could affect peritoneal host resistance in a manner similar to that observed after peritoneal administration. These studies showed that subcutaneous administration of AII throughout the postinfection interval increased the level of host resistance to bacterial peritonitis. Furthermore, in a study which compared AII and Neupogen, an agent approved for use for the reduction of febrile neutropenia after myeloablative therapy, daily subcutaneous administration of AII reduced abscess size and incidence, whereas Neupogen did not have any therapeutic benefit in this model. These data suggest that AII may be of therapeutic benefit as an immunomodulatory agent.
机译：其他实验室的研究表明，血管紧张素II（AII）可以影响组成免疫系统的细胞的功能。在本研究中，评估了AII对腹膜巨噬细胞和外周血单核细胞功能的影响。小鼠和大鼠的腹膜巨噬细胞在体外暴露于AII（测定前4小时）会增加吞噬调理酵母的细胞百分比和每个巨噬细胞的酵母数量。此外，AII增加了来自小鼠和大鼠的腹膜巨噬细胞和来自人类的外周血单个核细胞的呼吸爆发能力。由于这些观察，评估了AII对宿主对细菌感染的抵抗力的影响。在细菌性腹膜炎的动物模型中，腹膜内给予AII可增加宿主抵抗力（减少脓肿形成）。然后进行研究以评估肠胃外给药AII（一种临床相关途径）是否可能以与腹膜给药后类似的方式影响腹膜宿主抵抗力。这些研究表明，在感染后的整个时间间隔内，皮下注射AII可提高宿主对细菌性腹膜炎的抵抗力。此外，在一项比较AII和Neupogen的研究中，该药物被批准用于减少清髓性治疗后的发热性中性粒细胞减少症，每天皮下注射AII可以减少脓肿的大小和发生率，而Neupogen在该模型中没有任何治疗益处。这些数据表明AII作为免疫调节剂可能具有治疗益处。

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