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Association of Low Concentrations of Serum Mannose-Binding Protein with Recurrent Infections in Adults

机译：低浓度甘露糖结合蛋白与成人反复感染的关系

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Low concentrations of mannose-binding protein (MBP; also known as mannose-binding lectin) are associated with common opsonic defect in immunodeficient children. We compared the concentrations of MBP in the sera of 47 adults with non-human immunodeficiency virus-related recurrent infections (group I) and 50 healthy adult controls. Mean serum MBP concentrations in the patient group did not differ significantly from those in the control group (P < 0.4). Nevertheless, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in the patient group (21%, P = 0.01) than in the control group (4%). Group II consisted of 73 pediatric and 56 adult patients with recurrent infections. Pediatric patients had significantly lower mean concentrations of serum MBP than their controls (P < 0.005), and there was no significant difference between the concentrations in sera of adult patients and adult controls (P < 0.4). Again, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in both pediatric (22%, P = 0.045) and adult (38%,P = 0.000016) patients than in their respective controls (4%). Our results demonstrate that, as in children, low concentrations of serum MBP can be associated with recurrent infections in adults.
机译：低浓度的甘露糖结合蛋白（MBP;也称为甘露糖结合凝集素）与免疫缺陷儿童常见的调理素缺陷有关。我们比较了47例患有非人类免疫缺陷病毒相关反复感染的成年人（I组）和50例健康成年人的血清中MBP的浓度。患者组的平均血清MBP浓度与对照组无显着差异（ P <0.4）。然而，患者组中每毫升血清MBP低于5 ng的个体比例（21％， P = 0.01）显着高于对照组（4％）。第二组由73例儿科患者和56例反复感染的成人患者组成。小儿患者的血清MBP平均浓度显着低于对照组（ P <0.005），成年患者和成年对照组（ P <0.4）。同样，在儿童（22％， P = 0.045）和成人（38％， P = 0.000016）的患者比其各自的对照组（4％）。我们的结果表明，与儿童一样，低浓度的血清MBP可能与成人反复感染有关。

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