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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Korean Red Ginseng Slows Depletion of CD4 T Cells in Human Immunodeficiency Virus Type 1-Infected Patients
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Korean Red Ginseng Slows Depletion of CD4 T Cells in Human Immunodeficiency Virus Type 1-Infected Patients

机译：高丽红参减慢了人类免疫缺陷病毒1型感染患者中CD4 T细胞的消耗。

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We have previously showed that long-term intake of Korean red ginseng (KRG) delayed disease progression in human immunodeficiency virus type 1 (HIV-1)-infected patients. In the present study, to investigate whether this slow progression was affected by KRG intake alone or in combination with HLA factor, we analyzed clinical data in 68 HIV-1-infected patients who lived for more than 5 years without antiretroviral therapy. The average KRG intake over 111.9 ± 31.3 months was 4,082 ± 3,928 g, and annual decrease in CD4 T cells was 35.0 ± 28.7/μl. Data analysis showed that there are significant inverse correlations between the HLA prognostic score (0.29 ± 1.19) and annual decrease in CD4 T cells (r = ?0.347; P < 0.01) as well as between the amount of KRG intake and annual decrease in CD4 T cells (r = ?0.379; P < 0.01). In addition, KRG intake significantly slowed the decrease in CD4 T cells even when influence of HLA class I was statistically eliminated (repeated-measure analysis of variance; P < 0.05). We also observed significant correlation between KRG intake and a decrease in serum-soluble CD8 antigen level (r = 0.62; P < 0.001). In conclusion, these data show that KRG intake independently and significantly affected the slow depletion of CD4 T cells irrespective of HLA class I.
机译：先前我们已经表明，长期摄入高丽红参（KRG）会延迟1型人类免疫缺陷病毒（HIV-1）感染患者的疾病进展。在本研究中，为了调查这种缓慢的进展是否受单独的KRG摄入或与HLA因子联合使用的影响，我们分析了68例经抗HIV-1感染且未接受抗逆转录病毒治疗的5年以上患者的临床数据。在111.9±31.3个月中，平均KRG摄入量为4,082±3,928 g，CD4 T细胞的年度减少量为35.0±28.7 /μl。数据分析显示HLA预后评分（0.29±1.19）与CD4 T细胞的年度减少之间存在显着的负相关（ r = 0.347; P <0.01）以及KRG摄入量与CD4 T细胞的年度减少之间（ r = 0.379; P <0.01）。此外，即使在统计学上消除了HLA I类的影响，KRG摄入量也显着减缓了CD4 T细胞的减少（重复测量方差分析; P <0.05）。我们还观察到KRG摄入量与血清可溶性CD8抗原水平降低之间显着相关（ r = 0.62; P <0.001）。总之，这些数据表明，与HLA I类无关，KRG的摄入独立且显着影响CD4 T细胞的缓慢耗竭。

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