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Dissecting protein interactions during cytokinesis

机译：剖析胞质分裂过程中的蛋白质相互作用

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Appropriate assembly and constriction of the acto-myosin based contractile ring is essential for the final separation of the two daughter cells in mitosis. This is orchestrated by the small GTPase Rho as well as convergent signals from the prior events of mitosis. Contractile ring assembly requires the physical interaction of structural proteins like the microtubules of the central spindle, motor proteins and Rho activators. These and the interaction of newly localized proteins downstream of active Rho are essential for stability of the contractile ring and its proper constriction. Here, we discuss our recent findings that reveal a complex network of protein interactions during the early stages of cytokinesis. This includes evidence for a direct interaction between Polo Kinase and RacGAP50C as well as unpublished data suggesting other interactions of interest within the contractile ring.
机译：基于肌动蛋白的收缩环的适当组装和收缩对于有丝分裂中两个子细胞的最终分离至关重要。这是由小的GTPase Rho以及先前有丝分裂事件的会聚信号精心策划的。收缩环组装需要结构蛋白的物理相互作用，例如中心纺锤体的微管，运动蛋白和Rho激活剂。这些和活性Rho下游新定位的蛋白质的相互作用对于收缩环的稳定性及其适当的收缩至关重要。在这里，我们讨论了我们最近的发现，这些发现揭示了胞质分裂早期阶段蛋白质相互作用的复杂网络。这包括Polo激酶和RacGAP50C之间直接相互作用的证据，以及未公开的数据，表明收缩环内还存在其他感兴趣的相互作用。

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