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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Procalcitonin Does Not Discriminate Infection from Inflammation after Allogeneic Bone Marrow Transplantation
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Procalcitonin Does Not Discriminate Infection from Inflammation after Allogeneic Bone Marrow Transplantation

机译：降钙素原不能区分异体骨髓移植后炎症的感染。

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Procalcitonin (PCT) is an early marker of bacterial infection but little is known about its value in neutropenic allogeneic bone marrow transplant (BMT) recipients. We collected plasma from 12 recipients of T-cell-depleted HLA-matched related BMT recipients who had been treated preemptively with meropenem from the day after BMT for at least 15 days. PCT and C-reactive protein (CRP) concentrations were determined on BMT days 1, 5, 8, 12, and 15, and their relationship to inflammatory events (IE), including mucositis, microbiologically and clinically defined infections, acute graft-versus-host disease (GVDH), and unexplained fever, was then determined. The PCT concentrations were all low and never exceeded 4 μg/liter, unlike CRP concentrations, which spanned the full range up to 350 mg/liter. All patients had mucositis, and there was no significant difference between PCT concentrations associated with mucositis alone and those associated with an additional IE on BMT days 1 to 12. However, on BMT day 15, the mean concentrations of PCT were 0.37 ± 0.05 μg/liter for the 10 patients that had an additional IE, compared with 0.11 ± 0.03 μg/liter for the 2 patients with mucositis only (P = 0.012), and GVHD rather than infection was involved in six cases. PCT was also not a sensitive marker of gram-positive bacteremia or pulmonary aspergillosis. Thus, PCT is of little value in discriminating infections from other inflammatory complications that occur following allogeneic BMT.
机译：降钙素原（PCT）是细菌感染的早期标志物，但对其在中性粒细胞减少异基因骨髓移植（BMT）受体中的价值了解甚少。我们从BMT后第二天开始接受美罗培南抢先治疗的T细胞衰竭HLA匹配的相关BMT受体的12位受体中收集了血浆，这些患者从BMT后第二天开始接受了至少15天的治疗。在BMT第1、5、8、12和15天确定PCT和C反应蛋白（CRP）的浓度，以及它们与炎症事件（IE）的关系，包括粘膜炎，微生物和临床确定的感染，急性移植物抗-然后确定宿主疾病（GVDH）和无法解释的发热。 PCT浓度都很低，并且从未超过4μg/升，这与CRP浓度不同，CRP的整个范围高达350 mg /升。所有患者均患有粘膜炎，在BMT第1至12天，与粘膜炎相关的PCT浓度与与其他IE相关的PCT浓度之间无显着差异。但是，在BMT第15天，PCT的平均浓度为0.37±0.05μg/ 10例有IE的患者每升升为0.11±0.03μg/升，而2例只有粘膜炎的患者为（ P = 0.012），其中6例涉及GVHD而不是感染。 PCT也不是革兰氏阳性菌血症或肺曲霉病的敏感标志物。因此，PCT在区分感染与同种异体BMT后发生的其他炎症并发症方面几乎没有价值。

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