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首页> 外文期刊>Leukemia and lymphoma >Myeloid and lymphoid recovery following allogeneic bone marrow transplantation: a comparative study between related, unrelated bone marrow and allogeneic peripheral stem cell transplantation.
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Myeloid and lymphoid recovery following allogeneic bone marrow transplantation: a comparative study between related, unrelated bone marrow and allogeneic peripheral stem cell transplantation.

机译：同种异体骨髓移植后的髓样和淋巴样恢复：相关，不相关的骨髓与同种异体外周干细胞移植之间的比较研究。

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摘要

We studied myeloid and lymphoid recovery during a period of 12 months following HLA matched allogeneic bone marrow transplantation (BMT) in 15 patients. Patients were divided into three groups. Each group contained 5 patients according to the source of hematopoietic stem cell transplantation (HST): 1) related bone marrow transplantation (BMT), 2) allogeneic peripheral blood stem cell transplantation (PBSCT) and 3) matched unrelated donor transplantation (MUD). The rate and pattern of recovery of granulocytes, lymphocytes (T-cell subsets, B-cells, NK cells, subsets of CD45) were studied by cell counting and flow cytometry. Our results suggest faster recovery of PMN after PBSCT. Higher CD4 cell counts observed in the PBSCT group may have an impact on a lower incidence of opportunistic infections. Chronic GvHD mediated GvL effect seems to be more important in blood stem cell transplanted patients and this may have an influence on disease free survival.
机译：我们研究了15例HLA匹配异体骨髓移植（BMT）后12个月内的髓样和淋巴样恢复。患者分为三组。根据造血干细胞移植（HST）的来源，每组包括5名患者：1）相关的骨髓移植（BMT），2）同种异体外周血干细胞移植（PBSCT）和3）匹配的无关供体移植（MUD）。通过细胞计数和流式细胞术研究了粒细胞，淋巴细胞（T细胞亚群，B细胞，NK细胞，CD45亚群）的恢复速率和模式。我们的结果表明，PBSCT后PMN的恢复更快。在PBSCT组中观察到较高的CD4细胞计数可能会对机会性感染的较低发生率产生影响。慢性GvHD介导的GvL效应在血液干细胞移植患者中似乎更为重要，这可能会影响无病生存。

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