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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Contribution of Serum Immunoglobulin Transudate to the Antibody Immune Status of Murine Intestinal Secretions: Influence of Different Sampling Procedures
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Contribution of Serum Immunoglobulin Transudate to the Antibody Immune Status of Murine Intestinal Secretions: Influence of Different Sampling Procedures

机译：血清免疫球蛋白渗出物对小鼠肠道分泌物抗体免疫状态的贡献：不同采样程序的影响。

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摘要

Serum immunoglobulin transudation into the murine gut after intragastric immunization with the model antigen ovalbumin and cholera toxin adjuvant was investigated with regard to the mucosal sampling technique applied. The levels of serum-derived immunoglobulin A (IgA) turned out to be lowest in feces, intermediate in gut lavage fluid specimens, and highest in filter wick-collected samples. However, these levels did not exceed 2% of total and specific IgA in any mucosal sample type, except after the administration of very high antigen doses (≥1 mg of antigen per g of body weight), when transudation rates of up to 31% could be measured in filter wick-collected samples from individual animals. Luminal IgG was plasma transudate and/or bile borne and appeared to be reabsorbed at the mucosa to some extent.
机译：根据应用的粘膜采样技术，研究了使用模型抗原卵清蛋白和霍乱毒素佐剂进行胃内免疫后血清免疫球蛋白渗入小鼠肠道的情况。血清来源的免疫球蛋白A（IgA）的水平在粪便中最低，在灌肠液样本中居中，而在滤芯收集的样本中最高。但是，这些水平在任何粘膜样品类型中均不超过总IgA和特异性IgA的2％，但当灌出率高达31％时，施用非常高的抗原剂量（每g体重≥1 mg抗原）后，可以从个别动物的滤芯收集的样本中测量。发光的IgG是血浆渗出液和/或胆汁携带的，并且似乎在一定程度上在粘膜被重吸收。

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