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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Immunity to Human Immunodeficiency Virus (HIV) in Children with Chronic HIV Infection Receiving Highly Active Antiretroviral Therapy
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Immunity to Human Immunodeficiency Virus (HIV) in Children with Chronic HIV Infection Receiving Highly Active Antiretroviral Therapy

机译：接受高活性抗逆转录病毒疗法治疗的慢性HIV感染儿童的人免疫缺陷病毒（HIV）免疫

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Our objective was to describe the CD4-mediated human immunodeficiency virus (HIV)-specific cell-mediated immunity (CMI) and its virologic and immunologic correlates in children with chronic HIV infection on highly active antiretroviral therapy (HAART). Twelve HIV-infected children on stable antiretroviral therapy with a median level of CD4+ lymphocytes (CD4%) of 25.5% and a median viral load (VL) of 786 HIV RNA copies/ml were enrolled in this study. Nine of these children were also cytomegalovirus (CMV) seropositive. Blood mononuclear cells, stimulated with HIV and CMV antigens, were used to measure lymphocyte proliferation and to enumerate gamma interferon (IFN-γ)-producing CD4+ cells. HIV CMI and CMV CMI were detected in similar proportions of patients and correlated with each other, although the HIV responses were less robust. HIV lymphocyte proliferation significantly increased with lower HIV VL and showed a trend to increase with higher CD4% and longer time on HAART. The in vitro IFN-γ response to HIV or CMV was not affected by CD4%, VL, or HAART. Pediatric patients with established HIV infection on HAART frequently exhibit HIV CMI despite undetectable HIV replication. We concluded that the association between HIV CMI and CMV CMI indicates that the same factors govern responsiveness to either antigen.
机译：我们的目的是描述在CD40介导的人类免疫缺陷病毒（HIV）特异性细胞介导的免疫（CMI）及其病毒学和免疫学相关性的慢性HIV感染的儿童积极抗逆转录病毒疗法（HAART）。招募了十二名接受稳定抗病毒治疗的HIV感染儿童，其中CD4 + 淋巴细胞的平均水平（CD4％）为25.5％，病毒载量（VL）的平均水平为786 HIV RNA复制/毫升研究。这些孩子中有9名也是血清巨细胞病毒（CMV）阳性。用HIV和CMV抗原刺激的血液单核细胞用于测量淋巴细胞增殖，并计数产生γ-干扰素（IFN-γ）的CD4 + 细胞。尽管艾滋病毒的反应强度不高，但在患者中检测到的HIV CMI和CMV CMI比例相似，并且彼此相关。 HIV VL越低，HIV淋巴细胞的增殖就越明显，而CD4％越高，HAART的使用时间越长，HIV淋巴细胞的增殖趋势就会增加。对HIV或CMV的体外IFN-γ反应不受CD4％，VL或HAART的影响。尽管无法检测到HIV复制，但在HAART上已建立HIV感染的小儿患者经常出现HIV CMI。我们得出的结论是，HIV CMI和CMV CMI之间的关联表明相同的因素决定了对任一抗原的反应性。

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