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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Anemia and Interleukin-10, Tumor Necrosis Factor Alpha, and Erythropoietin Levels among Children with Acute, Uncomplicated Plasmodium falciparum Malaria
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Anemia and Interleukin-10, Tumor Necrosis Factor Alpha, and Erythropoietin Levels among Children with Acute, Uncomplicated Plasmodium falciparum Malaria

机译：急性单纯性恶性疟原虫患儿的贫血和白细胞介素10，肿瘤坏死因子α和促红细胞生成素水平

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Anemia is an important complication of malaria, and its pathogenesis is not well understood. To gain insight into potential age-related relationships between tumor necrosis factor alpha (TNF-α), interleukin 10 (IL-10), erythropoietin, and anemia during acute malaria, 273 children of ages 12 to 120 months presenting with acute, uncomplicated malaria in Kampala, Uganda, were monitored at enrollment and 3 and 7 days later. Younger children had higher geometric mean erythropoietin, TNF-α, and α1-acid glycoprotein (AGP) concentrations than older children. Univariate regression analysis revealed that age, log10 erythropoietin levels, IL-10/TNF-α ratio, and AGP levels were each significantly associated with hemoglobin levels at baseline. Hemoglobin concentrations were inversely correlated with the log10erythropoietin level at all three visits. For the older age groups, higher levels of TNF-α were significantly associated with higher IL-10 levels at all three visits, but this relationship was significant only at baseline for younger children. These data suggest that younger children do not maintain IL-10 production in response to the inflammatory process, and this mechanism may contribute to the more severe anemia found in younger children. Acute malaria is an illness whose incidence and severity are largely age dependent. Further studies are needed to understand the relationships between age-related immune responses to malaria and their role in the pathogenesis of malarial anemia.
机译：贫血是疟疾的重要并发症，其发病机理尚不十分清楚。为了洞悉急性疟疾期间肿瘤坏死因子α（TNF-α），白细胞介素10（IL-10），促红细胞生成素和贫血之间潜在的年龄相关关系，共有12至120个月的273名儿童出现了急性单纯性疟疾在入学时以及3天和7天后，对乌干达坎帕拉的居民进行了监测。年龄较小的儿童比年龄较大的儿童具有更高的几何平均促红细胞生成素，TNF-α和α 1 -酸糖蛋白（AGP）浓度。单因素回归分析显示，年龄，log 10 促红细胞生成素水平，IL-10 /TNF-α比值和AGP水平均与基线时的血红蛋白水平显着相关。在所有三个访视中，血红蛋白浓度与log 10 促红细胞生成素水平呈负相关。对于年龄较大的人群，在所有三个访视中，较高的TNF-α水平与较高的IL-10水平显着相关，但这种关系仅在年幼儿童的基线时才显着。这些数据表明，年龄较小的儿童在炎症过程中并未维持IL-10的产生，并且这种机制可能导致年龄较小的儿童出现更严重的贫血。急性疟疾是一种疾病，其发病率和严重程度在很大程度上取决于年龄。需要进一步的研究来了解与年龄相关的对疟疾的免疫反应及其在疟疾贫血发病机理中的作用之间的关系。

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