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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Reliability of CD4 Quantitation in Human Immunodeficiency Virus-Positive Children: Implications for Definition of Immunologic Response to Highly Active Antiretroviral Therapy
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Reliability of CD4 Quantitation in Human Immunodeficiency Virus-Positive Children: Implications for Definition of Immunologic Response to Highly Active Antiretroviral Therapy

机译：CD4定量在人类免疫缺陷病毒阳性儿童中的可靠性：对高度积极的抗逆转录病毒疗法的免疫反应的定义的含义。

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Our objective was to develop data-based algorithms for definition of immunologic response to AIDS therapies in pediatric patients, taking account of T-cell subset measurement errors. The study design involved cross-protocol analysis of 2,148 enrollees in six completed Pediatric AIDS Clinical Trials Group trials. We used standard quantitation of T-cell subsets; linear modeling with mean-dependent measurement error variance was used to develop 95% tolerance limits for change in CD4%. For individuals with a CD4% of approximately 25%, the measurement error-based 95% tolerance interval ranges from 15% to 35%, whereas for individuals with a CD4% of approximately 5%, the tolerance interval ranges from 3% to 7%. When pairs of CD4% measures taken within a time interval of less than 30 days are averaged to estimate steady-state CD4%, tolerance interval width decreases by approximately 30%. A simple graphical tool that provides a data-based criterion for immunologic response over and above variation ascribable to T-cell measurement error is provided. Variability in CD4% due to measurement error is substantial, increases with level of CD4%, and complicates assessment of immunologic response to therapy. Replicates of CD4% measures could be used to improve precision of interpretation of CD4% measures.
机译：我们的目标是考虑到T细胞亚群的测量误差，开发基于数据的算法来定义小儿患者对AIDS治疗的免疫反应。该研究设计涉及6项完整的儿科AIDS临床试验小组试验中对2,148名受试者的跨方案分析。我们使用了T细胞亚群的标准定量方法。线性模型与均值相关的测量误差方差用于建立CD4％变化的95％公差极限。对于CD4％约为25％的个体，基于测量误差的95％公差区间为15％至35％，而对于CD4％约为5％的个体，公差区间为3％至7％。 。当在少于30天的时间间隔内对成对的CD4％测量值进行平均以估计稳态CD4％时，容差间隔宽度将减少约30％。提供了一种简单的图形工具，该工具可为基于T细胞测量误差的变异以外的免疫应答提供基于数据的标准。由于测量误差导致CD4％的变异性很大，随CD4％的水平而增加，并使对治疗的免疫反应的评估变得复杂。 CD4％量度的重复可用于提高CD4％量度的解释精度。

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