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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Reference Values of CD4 T Lymphocytes in Human Immunodeficiency Virus-Negative Adult Nigerians
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Reference Values of CD4 T Lymphocytes in Human Immunodeficiency Virus-Negative Adult Nigerians

机译：CD4 T淋巴细胞在人类免疫缺陷病毒阴性成年尼日利亚人中的参考价值

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A cross-sectional study that involved secondary analysis of data collected from 681 pregnant women and 183 miners (94 men and 89 women; ratio of men to women, 1:0.95) in Jos, Nigeria, was carried out to determine the reference ranges for CD4+-cell counts in healthy HIV-negative adult Nigerians. The main results of interest were CD4+-cell counts and odds ratios (ORs) of low CD4+-cell counts, defined as below 350 cells per μl. CD4+-cell counts were similar in men and nonpregnant women, with a mean (standard deviation) of 828 (203) cells per μl, but pregnant women had a lower value of 771 (250) cells per μl. None of the factors assessed was related to the odds of having a low CD4+-cell count among men and nonpregnant women, but age, age of marriage, and alcohol usage were significant predictors in pregnant women. Compared to pregnant women less than 20 years old, older women had significantly lower odds of a low CD4+-cell count (ORs were 0.06 for women aged 20 to 29 years and 0.22 for those aged 30 to 39 years). When compared with those pregnant women who were married before 20 years of age, those who married at 20 to 29 years and 30 to 39 years had odds ratios of 6.41 and 9.40, respectively. Previous alcohol use was also associated with low CD4+-cell counts (OR, 5.15). The 95% confidence interval for CD4+-cell counts in healthy adult Nigerians is 547 to 1,327 cells per μl, and this is the first time this has been determined.
机译：进行了一项横断面研究，该研究包括对尼日利亚乔斯市从681名孕妇和183名矿工（94名男性和89名女性;男女比例为1：0.95）收集的数据进行的二次分析，以确定参考值范围。健康的HIV阴性成年尼日利亚人CD4 + 细胞计数。感兴趣的主要结果是CD4 + -细胞计数和低CD4 + -细胞计数的比值比（OR），定义为每μl低于350个细胞。男性和未怀孕女性的CD4 + 细胞计数相似，平均（标准差）为每微升828（203）个细胞，但孕妇的平均值则为每微升771（250）个细胞。微升评估的因素均与男性和非孕妇中CD4 + -细胞计数低的几率有关，但年龄，结婚年龄和饮酒是孕妇的重要预测指标。与20岁以下的孕妇相比，老年妇女的CD4 + -细胞计数低的几率明显更低（20至29岁妇女的OR为0.06，30至39岁妇女的OR为0.22年份）。与那些在20岁之前结婚的孕妇相比，在20至29岁和30至39岁结婚的孕妇的几率分别为6.41和9.40。先前的饮酒也与低CD4 + -细胞计数有关（OR，5.15）。健康成年尼日利亚人中CD4 + -细胞计数的95％置信区间为547至1,327细胞/μl，这是首次确定。

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