Transforming growth factor beta in Alzheimer's disease.

C C Chao; S Hu; W H Frey; T A Ala; W W Tourtellotte; P K Peterson

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Transforming growth factor beta in Alzheimer's disease.

机译：在阿尔茨海默氏病中转化生长因子β。

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Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.

机译：阿尔茨海默氏病（AD）被认为是一种炎症性疾病。我们假设抗炎细胞因子（例如转化生长因子β（TGF-beta））可以抵消炎症过程。在本研究中，我们发现从死后不到6小时的AD患者获得的脑脊液和血清样本中TGF-β的水平均升高。死亡前血清TGF-β水平也明显升高。这些结果表明，AD中TGF-β水平升高可能代表了对免疫介导的神经元损伤的保护性宿主反应。

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《Clinical and diagnostic laboratory immunology》 |1994年第1期|共2页
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C C Chao; S Hu; W H Frey; T A Ala; W W Tourtellotte; P K Peterson;
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1. Expression of vascular endothelial growth factor (VEGF), hypoxia inducible factor 1 alpha (HIF-1alpha), and transforming growth factors beta1 (TGFbeta1) and beta3 (TGFbeta3) in gestational trophoblastic disease. [J] . Bolat F, Haberal N, Tunali N, Pathology Research and Practice . 2010,第1期

机译：妊娠滋养细胞疾病中血管内皮生长因子（VEGF），缺氧诱导因子1α（HIF-1alpha）和转化生长因子beta1（TGFbeta1）和beta3（TGFbeta3）的表达。
2. Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease. [J] . Ongali B, Nicolakakis N, Lecrux C, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2010,第6期

机译：过表达APP和转化生长因子-β1的转基因小鼠具有阿尔茨海默氏病的认知和血管标志。
3. Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease. [J] . Ongali B, Nicolakakis N, Lecrux C, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2010,第6期

机译：过表达APP和转化生长因子-β1的转基因小鼠具有阿尔茨海默氏病的认知和血管标志。
4. LC/SRM Reveals Amyloid-beta Isoforms' Metabolic Differences and Diurnal Fluctuations in Alzheimer's Disease. [C] . Kwasi G. Mawuenyega, Vitaliy Ovod, Rachel Potter, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：LC / SRM揭示淀粉样蛋白β同种型在阿尔茨海默病中的代谢差异和昼夜波动。
5. Transforming growth factor-beta1 activation and transforming growth factor-beta receptor 2 expression levels in the regulation of the TGF-beta signaling pathway. [D] . Rojas, Andres. 2008

机译：在调节TGF-beta信号通路中转化生长因子-beta1激活和转化生长因子-beta受体2的表达水平。
6. Transforming growth factor beta in Alzheimers disease. [O] . C C Chao, S Hu, W H Frey 2nd, 1994

机译：在阿尔茨海默氏病中转化生长因子β。
7. Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [O] . Baugé, Catherine, Cauvard, Olivier, Leclercq, Sylvain, 2015

机译：调节转化生长因子β信号通路基因通过转化人骨关节炎软骨细胞中的生长因子β： sp1参与早期和晚期反应细胞的转化生长因子β
8. Initial Biochemical Characterization of Cells Derived from Human Periodontium and Their In vitro Response to Platelet-Derived Growth Factor, Epidermal Growth Factor and Transforming Growth Factor-Beta [R] . Piche', J. E. 1988

机译：人牙周组织细胞的初步生化特征及其对血小板衍生生长因子，表皮生长因子和转化生长因子-β的体外反应

Transforming growth factor beta in Alzheimer's disease.

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