...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and diagnostic laboratory immunology >Flow cytometric analyses of the lymphocyte subsets in peripheral blood of children with untreated active juvenile dermatomyositis.
【24h】

Flow cytometric analyses of the lymphocyte subsets in peripheral blood of children with untreated active juvenile dermatomyositis.

机译：未经治疗的活动性青少年皮肌炎患儿外周血淋巴细胞亚群的流式细胞仪分析。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Juvenile dermatomyositis (JDMS) is a vasculopathy affecting primarily skin and muscle. Although the etiology is unknown, immunopathogenetic mechanisms appear to play a role in both the susceptibility to the disease and its progression. We measured the percentage and absolute numbers of B cells and T-cell subsets in the peripheral blood of untreated JDMS patients with active early disease and compared the results with those obtained from a study of peripheral blood obtained from a heatlhy age-related control group. The absolute number of total lymphocytes in the peripheral blood of the JDMS patients was significantly lower (P < 0.002) than that observed in the healthy control population, with an associated decrease in the absolute number of all T-cell subsets. No concomitant decrease in the absolute number of B lymphocytes was observed in the JDMS patients. In contrast, the percentage of B lymphocytes and the T-helper/T-suppressor cell ratio were significantly higher in the JDMS group than in the control group (P < 0.001 and P < 0.002, respectively). Retrospective analysis of JDMS patients' serum samples obtained within 1 month of the flow cytometric evaluation indicated that 79% of the sera contained an antinuclear antibody and 46% had immunoglobulin G values above age-adjusted reference ranges. The increased percentage of B cells, the increased T-helper/T-suppressor cell ratio, the positive antinuclear antibody results, and the increased concentration of serum immunoglobulin suggest that humoral immune dysregulation may contribute to the pathogenesis of JDMS.
机译：少年皮肌炎（JDMS）是一种主要影响皮肤和肌肉的血管病。尽管病因尚不清楚，但免疫病理机制似乎在对该疾病的易感性及其进展中均起作用。我们测量了患有活动性早期疾病的未经治疗的JDMS患者外周血中B细胞和T细胞亚群的百分比和绝对数，并将结果与​​从健康年龄相关对照组的外周血研究中获得的结果进行了比较。 JDMS患者外周血中总淋巴细胞的绝对数显着低于健康对照组的患者（P <0.002），并且所有T细胞亚群的绝对数都相应减少。在JDMS患者中未观察到B淋巴细胞绝对数量的同时减少。相反，JDMS组的B淋巴细胞百分比和T辅助/ T抑制细胞比率明显高于对照组（分别为P <0.001和P <0.002）。对流式细胞术评估后1个月内获得的JDMS患者血清样品的回顾性分析表明，79％的血清中含有抗核抗体，46％的血清中的免疫球蛋白G值超过了年龄调整的参考范围。 B细胞百分比增加，T辅助/ T抑制细胞比例增加，抗核抗体阳性结果增加以及血清免疫球蛋白浓度增加表明体液免疫失调可能与JDMS的发病机理有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号