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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Multireactive pattern of serum autoantibodies in asymptomatic individuals with immunoglobulin A deficiency.
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Multireactive pattern of serum autoantibodies in asymptomatic individuals with immunoglobulin A deficiency.

机译：具有免疫球蛋白A缺乏症的无症状个体的血清自身抗体的多反应性模式。

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Selective immunoglobulin A (IgA) deficiency (sIgAD) is associated with certain autoimmune states. Increased production of autoantibodies and eventual development of overt autoimmune disease are related in part to genetic and environmental factors as well as to the immune deficiency. We surveyed serum specimens from 60 healthy subjects with sIgAD for the presence of 21 different autoantibodies by enzyme-linked immunosorbent assays. The frequencies of 16 autoantibodies were higher in sIgAD patients than in normal healthy controls. Autoantibodies to Jo-1 (28%), cardiolipin (21%), phosphatidylserine (20%), Sm (15%), asialo-GM1 (21%), sulfatide (32%), sulfoglucuronyl paragloboside (11%), and collagen type I (10%) were detected at high frequencies in comparison to those of normal healthy controls. Many of the serum samples were multireactive (i.e., exhibited binding to more than two autoantigens). Forty percent (24 of 60) of sIgAD serum samples reacted against six or more autoantigens; 10% (6 of 60) of sIgAD serum samples were not reactive with any of the 21 autoantigens. Three percent (7 of 209) of consecutive serum samples submitted for autoimmune antibody analysis that were positive for autoantibodies were from patients with IgA deficiency. Our finding of an increased frequency of autoantibodies in sIgAD patients supports the notion of polyclonal stimulation by repeated environmental stimuli as an etiologic mechanism. Alternatively, the increased frequency may be caused by a dysregulation of the immune response in such individuals. The mere detection of autoantibodies cannot predict whether a subject with sIgAD will develop an autoimmune disease or determine which specific disease will emerge.
机译：选择性免疫球蛋白A（IgA）缺乏症（sIgAD）与某些自身免疫状态有关。自身抗体产量的增加和最终自身免疫疾病的发展部分与遗传和环境因素以及免疫缺陷有关。我们通过酶联免疫吸附测定法对60例患有sIgAD的健康受试者的血清标本进行了调查，发现其中存在21种不同的自身抗体。 sIgAD患者中16种自身抗体的频率高于正常健康对照者。对Jo-1（28％），心磷脂（21％），磷脂酰丝氨酸（20％），Sm（15％），去唾液酸-GM1（21％），硫化物（32％），磺基葡糖醛酸旁糖苷（11％）和与正常健康对照相比，高频率检测到I型胶原蛋白（10％）。许多血清样品具有多重反应性（即与两种以上自身抗原结合）。 sIgAD血清样品中有百分之四十（60份中的24份）对六种或更多种自身抗原有反应; sIgAD血清样品中有10％（60个中的6个）与21种自身抗原中的任何一种都不反应。呈递给自身抗体阳性的，用于自身免疫抗体分析的连续血清样本中有百分之三（209个中的七个）来自IgA缺乏症患者。我们发现sIgAD患者自身抗体频率增加的发现支持通过反复环境刺激作为病因机制的多克隆刺激概念。备选地，增加的频率可能是由此类个体中免疫应答的失调引起的。仅检测自身抗体不能预测患有sIgAD的受试者是否会发展自身免疫性疾病或确定会出现哪种特定疾病。

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