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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Selective increases in antibody isotypes and immunoglobulin G subclass responses to secreted antigens in tuberculosis patients and healthy household contacts of the patients.
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Selective increases in antibody isotypes and immunoglobulin G subclass responses to secreted antigens in tuberculosis patients and healthy household contacts of the patients.

机译：结核病患者和患者健康家庭接触者对分泌抗原的抗体同种型和免疫球蛋白G亚类反应的选择性增加。

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Mycobacterium tuberculosis-specific antibodies (immunoglobulin M [IgM], IgE, IgG, and IgG subclasses) were determined in 164 tuberculosis patients (pulmonary involvement, n = 135; lymph node involvement, n = 29), 59 healthy household contacts (HC), and 51 healthy endemic donors (EC) by a quantitative enzyme-linked immunosorbent assay for reactivity with culture filtrate. Among the isotypes, significant differences between tuberculosis patient groups with either pulmonary or lymph node involvement and healthy control groups (HC and EC) were detected only for IgG (P < 0.001) and IgG1 (P < 0.001) antibodies. Pulmonary patients also showed a significant difference with IgM (P < 0.01) and IgE (P < 0.05) antibodies. HC showed elevation of only IgM antibodies compared with EC, indicating that IgM antibodies may be an indicator of recent infection with M. tuberculosis. These results suggest that the switching of IgM antibody response to IgG1 is a critical event in disease progression. Polyclonal IgG1, IgG3, and IgE antibodies also showed significant elevation (P < 0.05) in patients compared with EC. A strong correlation (rho = 0.254; P < 0.003) was observed between M. tuberculosis-specific IgG1 and polyclonal IgG1 in patients, suggesting that activations of antigen-specific and polyclonal antibodies are related events. No correlation was found between IgG1 antibodies and purified protein derivative skin test results. Since IgG1 antibody responses to culture filtrate are present only after disease establishment, IgG1 responses could provide a useful diagnostic marker of disease.
机译：在164例结核病患者（肺部受累，n = 135;淋巴结受累，n = 29），59个健康家庭接触者（HC）中确定了结核分枝杆菌特异性抗体（免疫球蛋白M [IgM]，IgE，IgG和IgG亚类） ，以及51种健康的地方性供体（EC），采用定量酶联免疫吸附法测定与培养物滤液的反应性。在同种型中，仅检测到IgG（P <0.001）和IgG1（P <0.001）抗体，肺或淋巴结受累的结核病患者组与健康对照组（HC和EC）之间存在显着差异。肺部患者也显示出IgM（P <0.01）和IgE（P <0.05）抗体的显着差异。 HC与EC相比仅显示IgM抗体升高，表明IgM抗体可能是近期感染结核分枝杆菌的指标。这些结果表明，IgM抗体对IgG1应答的转换是疾病进展中的关键事件。与EC相比，患者的多克隆IgG1，IgG3和IgE抗体也显示出显着升高（P <0.05）。在患者中，结核分枝杆菌特异性IgG1和多克隆IgG1之间存在很强的相关性（rho = 0.254; P <0.003），这表明抗原特异性和多克隆抗体的激活是相关事件。 IgG1抗体与纯化的蛋白衍生物皮肤测试结果之间未发现相关性。由于对培养物滤液的IgG1抗体应答仅在疾病确定后才存在，因此IgG1应答可以提供有用的疾病诊断标记。

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