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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Immune Response of Children Who Develop Persistent Diarrhea following Rotavirus Infection
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Immune Response of Children Who Develop Persistent Diarrhea following Rotavirus Infection

机译：轮状病毒感染后持续腹泻儿童的免疫应答

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A prospective study was conducted with Bangladeshi children with rotavirus (RV) diarrhea to assess whether nutritional and clinical parameters, RV serotypes, levels of interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ), and RV-specific antibody titers in plasma and stool were associated with the development of persistent diarrhea. Children with watery diarrhea for 6 to 8 days, selected from the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), were enrolled in the study and monitored until diarrhea improved. Children were classified as having acute diarrhea (AD) if diarrhea resolved within 14 days of onset and as having persistent diarrhea (PD) if diarrhea persisted for more than 14 days after onset. Uninfected, control children (n = 13) from the Nutrition Follow-Up Unit of ICDDR,B were also enrolled. Of the 149 children with diarrhea enrolled, 29 had diarrhea with RV alone, of which 19 had AD and 10 developed PD. Samples of stool and blood were collected from all children on enrollment. Stool samples were collected again from children when they developed PD. Of the 10 children who had an initial RV infection and then developed PD, only one had persistent RV infection. Plasma levels of IL-10 and TNF-α were higher in children with diarrhea compared to uninfected controls but were similar in children with AD and PD. Plasma IFN-γ levels were higher in children who developed PD than in those with AD (P = 0.008) or uninfected controls (P = 0.001). In stools, the levels of TNF-α, the only cytokine detected, were similar in the three groups of children. RV-specific immunoglobulin G (IgG) titers in plasma were higher in uninfected children than in those with AD (P < 0.001) or PD (P = 0.024) but titers were similar in children with AD and PD. RV-specific IgA titers in plasma and stool were similar in the three groups of children. From all observed parameters, only elevated plasma IFN-γ levels were associated with subsequent development of PD. However, a larger sample size is necessary to substantiate this observation.
机译：对孟加拉国轮状病毒（RV）腹泻儿童进行了一项前瞻性研究，以评估其营养和临床参数，RV血清型，白介素10（IL-10）水平，肿瘤坏死因子α（TNF-α）和γ干扰素（血浆和粪便中的IFN-γ）和RV特异性抗体滴度与持续性腹泻有关。从孟加拉国国际腹泻病研究中心（ICDDR，B）的达卡医院（DDDR）选出的6至8天的水样腹泻儿童入选本研究并进行监测，直至腹泻得到改善。如果腹泻在发病后14天之内消失，则儿童被分类为急性腹泻（AD）;如果腹泻在发病后持续超过14天，则归为持续性腹泻（PD）。来自ICDDR，B营养随访科的未感染对照儿童（ n = 13）也参加了研究。在入组的149例腹泻儿童中，有29例仅靠RV腹泻，其中19例患有AD，10例发展为PD。入选时从所有儿童中收集粪便和血液样本。当他们患PD时，再次从儿童那里收集粪便样本。在最初发生RV感染然后发展为PD的10名儿童中，只有一名持续性RV感染。与未感染的对照组相比，腹泻患儿的血浆IL-10和TNF-α含量较高，而AD和PD患儿的血浆IL-10和TNF-α含量较高。发生PD的儿童的血浆IFN-γ水平高于患有AD（ P = 0.008）或未感染对照（ P = 0.001）的儿童。在三组儿童中，粪便中检测到的唯一细胞因子TNF-α的水平相似。未感染儿童血浆中RV特异性免疫球蛋白G（IgG）滴度高于AD（ P <0.001）或PD（ P = 0.024）的儿童，但滴度为AD和PD患儿的情况相似。在三组儿童中，血浆和粪便中的RV特异性IgA滴度相似。从所有观察到的参数来看，仅血浆IFN-γ水平升高与PD的后续发展有关。但是，必须有更大的样本量才能证实该观察结果。

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