Lack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused by Staphylococcus aureus

Catrin E. Moore; Shelley Segal; Anthony R. Berendt; Adrian V. S. Hill; Nicholas P. J. Day

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Lack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused by Staphylococcus aureus

机译：Toll样受体2多态性与金黄色葡萄球菌引起的严重疾病的易感性之间缺乏关联

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To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

机译：研究Toll样受体2（TLR2）的遗传确定的变异与严重金黄色葡萄球菌的发生，功能性Arg753Gln单核苷酸多态性和TLR2基因中的GT重复微卫星之间的假定联系在大型病例对照研究中进行了检查。没有发现可归因于这些特征的疾病或死亡率。 展开▼

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《Clinical and diagnostic laboratory immunology》 |2004年第6期|共4页

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Catrin E. Moore; Shelley Segal; Anthony R. Berendt; Adrian V. S. Hill; Nicholas P. J. Day;
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1. Lack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused by Staphylococcus aureus [J] . Catrin E. Moore, Shelley Segal, Anthony R. Berendt, Clinical and diagnostic laboratory immunology . 2004,第6期

机译：Toll样受体2多态性与金黄色葡萄球菌引起的严重疾病的易感性之间缺乏关联

2. The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection [J] . El-Bendary M., Neamatallah M., Elalfy H., British journal of biomedical science . 2018,第4期

机译：单一核苷酸多态性的Toll样受体3，Toll样受体7和Toll样受体8基因的关联随着HCV感染的易感性

3. Lack of association between Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms and tuberculosis susceptibility: A meta-analysis [J] . Tian Tian, Jin Shuliang, Dong Jianchun, Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases . 2013,第Null期

机译：Toll样受体4基因Asp299Gly和Thr399Ile多态性与结核易感性之间缺乏关联：一项荟萃分析

4. SUSCEPTIBILITY TO PARATUBERCULOSIS IS ASSOCIATED WITH SINGLE NUCLEOTIDE POLYMORPHISMS IN BOVINE TOLL-LIKE RECEPTOR 2 [C] . A. KOETS, W. SANTEMA, H. MERTENS, Meeting of The Society for Veterinary Epidemiology and Preventive Medicine . 2009

机译：对副植物症的易感性与牛Toll样受体2中的单核苷酸多态性有关

5. Toll-like receptor (TLR) signaling and differential activation of PGC family genes in a mouse model of Staphylococcus aureus sepsis [D] . Sweeney, Timothy Elisha 2011

机译：金黄色葡萄球菌败血症小鼠模型中Toll样受体（TLR）信号传导和PGC家族基因的差异激活

6. Lack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused by Staphylococcus aureus [O] . Catrin E. Moore, Shelley Segal, Anthony R. Berendt, 2004

机译：Toll样受体2多态性与金黄色葡萄球菌引起的严重疾病的易感性之间缺乏关联

7. Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus. [O] . Moore, CE, Segal, S, Berendt, AR, 2004

机译：Toll样受体2多态性与金黄色葡萄球菌引起的严重疾病的易感性之间缺乏关联。

1. 中国汉族人群Toll样受体2基因多态性与肺结核易感性之间关系 [J] . 车南颖 ,姜世闻 ,高铁杰 . 中国防痨杂志 . 2011,第004期

2. 中国汉族人群Toll样受体2基因多态性与肺结核易感性之间关系 [J] . 车南颖 ,姜世闻 ,高铁杰 . 结核病与胸部肿瘤 . 2011,第002期

3. Toll样受体2基因Arg753Gln和CD14启动子-159C/T多态性与肺炎链球菌病易感性的Meta分析 [J] . 朱满桂 ,冯艳 ,李夏西 . 中国当代医药 . 2019,第002期

4. Toll样受体2基因多态性与胃癌及EB病毒相关胃癌易感性的关系 [J] . 卫美蓉 ,刘颂 ,赵真真 . 癌变·畸变·突变 . 2015,第005期

5. Toll样受体2及Toll样受体9基因多态性与胃癌易感性的关系 [J] . 曾红梅 ,游伟程 ,潘凯枫 . 中华预防医学杂志 . 2011,第007期

6. 中国汉族人群Toll样受体2基因多态性与肺结核易感性之间关系 [C] . 车南颖 ,姜世闻 ,高铁杰 . 2010年中国防痨协会临床/基础专业学术大会 . 2010

7. XYLT1基因多态性与汉族人群中噪声诱发的职业性听力损失易感性之间的关联 [A] . 王君 . 2018

1. 与冠心病易感性显著关联的易感区域chr2p24的单核苷酸多态性位点及其应用 [P] . 中国专利： CN102747073B . 2015.02.11

2. 与冠心病易感性关联的易感区域chr4q32的单核苷酸多态性位点及其应用 [P] . 中国专利： CN102747076B . 2014.12.24

3. ANTIMICROBIAL AGENT AGAINST STAPHYLOCOCCUS AUREUS, PROPHYLACTIC/THERAPEUTIC AGENT FOR DISEASE CAUSED BY STAPHYLOCOCCUS AUREUS AS PATHOGEN, AND SKIN CARE EXTERNAL PREPARATION INCLUDING THEM [P] . 外国专利： JP2013139412A . 2013-07-18

机译：金黄色葡萄球菌的抗菌剂，金黄色葡萄球菌引起的疾病的预防性/治疗性病原体，以及皮肤护理剂，包括它们

4. composition; pharmaceutical composition; combination therapy; medical apparatus; method for administering at least one glycylcycline and at least one heparin; method for the administration of glycylcycline and heparin; method of treating intraabdominal infections with complications (ciai) and cutaneous infections and complications of the cutaneous structure (csssi) caused by gram negative and gram positive pathogens, anaerobic and methicillin-resistant strains and those resistant to staphylococcus aureus ( mssa and mrsa); method of treating intraabdominal infections with complications (ciai) and infections of the cutaneous and complicating skin structure (csssi) caused by gram negative and gram positive pathogens, anaerobic and methicillin-resistant strains of staphylococcus aureus ( mssa and mrsa) in a patient in need; antibiotic administration method; article of manufacture; kit; use of a glycylcillin of formula I or a pharmaceutically acceptable salt thereof; use of a heparin or pha [P] . 外国专利： BRPI0611070A2 . 2010-08-03

机译：组成;药物组合物;联合疗法医疗器械至少一种缩水甘油环素和至少一种肝素的给药方法;甘氨酰环素和肝素的给药方法;治疗由革兰氏阴性和革兰氏阳性病原体，厌氧和耐甲氧西林的菌株以及对金黄色葡萄球菌有抵抗力的菌株（mssa和mrsa）引起的合并症（ciai）和腹腔内感染的并发症（ciai）和皮肤感染以及皮肤结构并发症（csssi）;革兰氏阴性和革兰氏阳性病原体，金黄色葡萄球菌厌氧和耐甲氧西林菌株（mssa和mrsa）引起的并发症（CIAI）和皮肤感染和皮肤复杂结构（CSSS）感染的腹腔内感染的治疗方法;抗生素给药方法;制品;套件式I的糖基西林或其药学上可接受的盐的用途;肝素或相的使用

5. COMPOSITION FOR PREVENTING OR TREATNG DISEASES CAUSED STAPHYLOCOCCUS AUREUS [P] . 外国专利： KR20100104723A . 2010-09-29

机译：预防或治疗金黄色葡萄球菌引起的疾病的组合物

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Lack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused by Staphylococcus aureus

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