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首页> 外文期刊>CNS neuroscience & therapeutics. >Comparison of Clinical Features in Patients with Persistent and Nonpersistent Cryptococcal Meningitis: Twelve Years of Clinical Experience in Four Centers in China
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Comparison of Clinical Features in Patients with Persistent and Nonpersistent Cryptococcal Meningitis: Twelve Years of Clinical Experience in Four Centers in China

机译：持续性和非持续性隐球菌性脑膜炎患者的临床特征比较：中国四个中心的十二年临床经验

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Summary Background and Aims Cryptococcal meningitis ( CM ) has gradually increased in the recent 20 years in the whole world. Although the mortality decreased significantly in recent years, it was still high, especially in patients with persistent infection. Therefore, we compare differences of clinical features between persistent and nonpersistent CM patients. Methods We conducted a retrospective review of medical records of patients diagnosed with CM from J anuary 2000 to D ecember 2011 in four centers in C hina, including demographic features, underlying diseases, clinical presentations, laboratory data, and so on. Results Of 106 CM patients enrolled, 16 were identified as persistent cases. Among all variables, persistent CM patients were more like to be human immunodeficiency viruses ( HIV ) infection ( P 400 mmH2O ( P 1:1024 ( P 400 mmH2O ( OR 6.83) were closely correlated with persistent CM . Conclusions Although it is difficult to deal with persistent CM nowadays, some cases could be predicted early enough in the future, so as to be treated appropriately and have relatively good outcomes.
机译：发明背景和目的隐球菌性脑膜炎（CM）在全世界近20年来逐渐增加。尽管近年来死亡率显着下降，但仍然很高，尤其是对于持续感染的患者。因此，我们比较了持续性和非持续性CM患者的临床特征差异。方法我们回顾性回顾了2000年1月至2011年12月在中国四个中心诊断为CM的患者的病历，包括人口统计学特征，潜在疾病，临床表现，实验室数据等。结果招募的106例CM患者中，有16例为持续性病例。在所有变量中，持续性CM患者更像是人类免疫缺陷病毒（HIV）感染（P 400 mmH2O（P 1：1024（P 400 mmH2O（OR 6.83）与持续性CM密切相关）结论尽管难以处理在当今持续性CM的情况下，可以在将来足够早地预测某些病例，以便对其进行适当治疗并取得相对较好的结果。

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