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首页> 外文期刊>CNS neuroscience & therapeutics. >A Cross‐Sectional Study on Cerebrospinal Fluid Biomarker Levels in Cognitively Normal Elderly Subjects With or Without a Family History of Alzheimer's Disease
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A Cross‐Sectional Study on Cerebrospinal Fluid Biomarker Levels in Cognitively Normal Elderly Subjects With or Without a Family History of Alzheimer's Disease

机译：有或没有阿尔茨海默氏病家族史的认知正常老年人中脑脊液生物标志物水平的横断面研究

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Summary Background Cerebrospinal fluid ( CSF ) biomarkers reflect changes in the brain, and contribute to early screening. Maternal inheritance is putatively stronger than paternal inheritance for late‐onset A lzheimer's disease ( LOAD ). Methods Clinical data of 162 cognitively normal subjects were reviewed. A standard questionnaire was used to identify LOAD family history. Mini‐mental state examination ( MMSE ) was used to evaluate cognition. CSF Aβ1‐40, Aβ1‐42, total and phosphorylated tau were measured using ELISA . Aims To compare biomarkers in cognitively normal elderly subjects with versus without LOAD family history. Results Among the 162 subjects, 38 and 60 had LOAD family history on paternal and maternal sides, respectively. The remaining 60 subjects had no family history. No difference was noted in age, gender, education level, MMSE score, and memory impairment complaint in the three groups. Aβ42 and the Aβ42/40 ratio were lower than in subjects with a maternal history than in subjects with a paternal history or without family history ( P Conclusion Offspring with a family history of LOAD on the maternal side have lower Aβ42 and Aβ42/40 ratio in the CSF , and maybe at higher risk for developing AD .
机译：背景技术脑脊液（CSF）生物标志物反映了大脑的变化，并有助于早期筛查。对于迟发性阿兹海默氏病（LOAD），推定母亲的遗传比父亲的遗传更强。方法对162例认知正常者的临床资料进行回顾。使用标准调查表确定LOAD家族史。迷你精神状态检查（MMSE）用于评估认知。使用ELISA测量CSFAβ1-40，Aβ1-42，总tau和磷酸化tau。目的比较有和没有LOAD家族史的认知正常老年人的生物标志物。结果在162名受试者中，分别有38名和60名在父亲和母亲方面有LOAD家族史。其余60名受试者没有家族史。三组患者的年龄，性别，教育程度，MMSE得分和记忆障碍投诉均无差异。 Aβ42和Aβ42/ 40的比率低于有母亲病史的受试者，低于有父亲病史或没有家族史的受试者（P结论母体侧有LOAD家族史的后代的Aβ42和Aβ42/ 40比率较低。脑脊液，可能罹患AD的风险更高。

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