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首页> 外文期刊>CNS neuroscience & therapeutics. >Reduced Frontal Activation during a Working Memory Task in Mild Cognitive Impairment: a Non‐Invasive Near‐Infrared Spectroscopy Study
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Reduced Frontal Activation during a Working Memory Task in Mild Cognitive Impairment: a Non‐Invasive Near‐Infrared Spectroscopy Study

机译：在轻度认知障碍的工作记忆任务中减少额叶激活：一项非侵入式近红外光谱研究

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Summary Aims Working memory ( WM ) impairments are considered to be a main feature of mild cognitive impairment ( MCI ). Functional brain imaging studies have revealed evidence of alterations in the frontal and temporal cortices associated with WM in MCI patients. However, some imaging methods are too expensive for routine clinical use and have a low temporal resolution. Methods Using a newly developed near‐infrared spectroscopy ( NIRS ) system, we studied the spatiotemporal dynamics of oxygenated hemoglobin (oxy‐Hb) during a WM task in eight patients with mild cognitive impairment ( MCI ) and 16 age‐ and gender‐matched healthy controls. Results We performed temporal and spatial correlation analyses on each group during their WM tasks. These results consistently demonstrated that, when compared with the healthy controls, the MCI patients exhibited significantly decreased activation in the left frontal, right superior frontal and left temporal lobes. We found evidence of altered frontal and temporal processing during WM tasks in the MCI patients. Conclusions These results confirm the functional deficits in the frontal and temporal cortices and the impairment of WM and cognitive abilities in MCI patients and suggest that fNIRS may be a useful tool for evaluating brain activation in cognitive disorders.
机译：摘要目标工作记忆（WM）障碍被认为是轻度认知障碍（MCI）的主要特征。功能性脑影像学研究已发现MCI患者与WM相关的额皮质和颞皮质改变的证据。然而，一些成像方法对于常规临床使用而言太昂贵并且具有低时间分辨率。方法使用新开发的近红外光谱（NIRS）系统研究了8名轻度认知障碍（MCI）患者和16名年龄和性别匹配的健康者在WM任务期间氧化血红蛋白（oxy-Hb）的时空动态控制。结果我们在每个小组的WM任务期间进行了时间和空间相关性分析。这些结果一致表明，与健康对照组相比，MCI患者在左额叶，右上额叶和左颞叶的激活明显降低。我们发现在MCI患者的WM任务期间额叶和颞叶处理发生改变的证据。结论这些结果证实了MCI患者额叶皮质和颞叶皮质的功能缺陷以及WM和认知能力的损害，并表明fNIRS可能是评估认知障碍中脑部激活的有用工具。

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