• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>CNS neuroscience & therapeutics. >Quetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair
【24h】

Quetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair

机译：富马酸喹硫平用于治疗多发性硬化症：以髓鞘修复为重点

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary Multiple sclerosis ( MS ) is a central nervous system disorder that is associated with progressive oligodendrocyte and neuronal loss, axonal degeneration, and demyelination. Several medications that mitigate immune abnormalities reduce both the frequency of relapses and inflammation on magnetic resonance imaging, leading to improved outcomes for people with the relapsing–remitting form of MS . However, there are no treatments for the progressive forms of MS where neurons and axons continue to degenerate; here, neuroprotective therapies, or medications that rebuild myelin to confer axonal well‐being, may be useful. Quetiapine fumarate is an atypical antipsychotic with reported remyelinating and neuroprotective properties in inflammatory and noninflammatory models of demyelination, including experimental autoimmune encephalomyelitis, and both cuprizone‐ and global cerebral ischemia‐induced demyelination. Preclinical studies suggest that quetiapine may exert these effects by stimulating proliferation and maturation of oligodendrocytes, releasing neurotrophic factors, increasing antioxidant defences, scavenging for free radicals, and inhibiting activated microglia, astrocytes, and T lymphocytes. Additionally, quetiapine may be beneficial for psychiatric and nonpsychiatric symptoms of MS including depression, anxiety, insomnia, and possibly even pain. These data indicate that clinical trials are justified to determine the safety, tolerability, and efficacy of quetiapine fumarate in MS .
机译：总结多发性硬化症（MS）是一种中枢神经系统疾病，与进行性少突胶质细胞和神经元丢失，轴突变性和脱髓鞘有关。几种缓解免疫异常的药物可减少磁共振成像上复发和发炎的频率，从而为患有复发-复发型MS的患者带来更好的治疗效果。但是，对于神经元和轴突持续退化的进行性MS尚无治疗方法。在这里，神经保护疗法或重建髓磷脂以赋予轴突健康的药物可能会有用。富马酸喹硫平是一种非典型抗精神病药，据报道在炎性和非炎性脱髓鞘模型（包括实验性自身免疫性脑脊髓炎），铜酮和全脑缺血引起的脱髓鞘中均具有髓鞘再生和神经保护作用。临床前研究表明，喹硫平可通过刺激少突胶质细胞的增殖和成熟，释放神经营养因子，增加抗氧化剂防御能力，清除自由基并抑制活化的小胶质细胞，星形胶质细胞和T淋巴细胞发挥这些作用。此外，喹硫平可能有益于MS的精神和非精神症状，包括抑郁，焦虑，失眠甚至可能是疼痛。这些数据表明临床试验可以确定富马酸喹硫平在MS中的安全性，耐受性和疗效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号