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首页> 外文期刊>CNS neuroscience & therapeutics. >Increase in Neuroexcitability of Unmyelinated C‐type Vagal Ganglion Neurons During Initial Postnatal Development of Visceral Afferent Reflex Functions
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Increase in Neuroexcitability of Unmyelinated C‐type Vagal Ganglion Neurons During Initial Postnatal Development of Visceral Afferent Reflex Functions

机译：内脏传入反射功能的出生后初期发育过程中，无髓鞘的C型迷走神经节神经元的神经兴奋性增加。

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Summary Background Baroreflex gain increase up closely to adult level during initial postnatal weeks, and any interruption within this period will increase the risk of cardiovascular problems in later of life span. We hypothesize that this short period after birth might be critical for postnatal development of vagal ganglion neurons ( VGN s). Methods To evaluate neuroexcitability evidenced by discharge profiles and coordinate changes, ion currents were collected from identified A‐ and C‐type VGN s at different developmental stages using whole‐cell patch clamping. Results C‐type VGN s underwent significant age‐dependent transition from single action potential ( AP ) to repetitive discharge. The coordinate changes between TTX ‐S and TTX ‐R Na+ currents were also confirmed and well simulated by computer modeling. Although 4‐ AP or iberiotoxin age dependently increased firing frequency, AP duration was prolonged in an opposite fashion, which paralleled well with postnatal changes in 4‐ AP ‐ and iberiotoxin‐sensitive K+ current activity, whereas less developmental changes were verified in A‐types. Conclusion These data demonstrate for the first time that the neuroexcitability of C‐type VGN s increases significantly compared with A‐types within initial postnatal weeks evidenced by AP discharge profiles and coordinate ion channel changes, which explain, at least in part, that initial postnatal weeks may be crucial for ontogenesis in visceral afferent reflex function.
机译：发明背景在出生后的最初几周内，压力反射的增益增加到成年人的水平，并且在此期间的任何中断都会增加生命后期出现心血管疾病的风险。我们假设出生后的这一短暂时期可能对迷走神经节神经元（VGN s）的出生后发育至关重要。方法为了评估由放电曲线和坐标变化证明的神经兴奋性，使用全细胞膜片钳从不同发育阶段识别出的A型和C型VGN收集离子电流。结果C型VGN经历了显着的年龄依赖性转变，从单动作电位（AP）到重复放电。 TTX-S和TTX-R Na +电流之间的坐标变化也得到了确认，并通过计算机建模进行了很好的模拟。尽管4AP或埃博毒素的年龄依赖于增加放电频率，但AP持续时间却以相反的方式延长，这与4AP和埃博毒素敏感的K +电流活动在出生后的变化非常吻合，而A型的发育变化较少。结论这些数据首次证明，在出生后最初的几周内，C型VGN的神经兴奋性较A型显着提高，这是由AP放电曲线和协调的离子通道变化所证实的，这至少部分解释了出生后的初始几周对于内脏传入反射功能中的肿瘤发生可能至关重要。

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