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The Beneficial Role of Thiamine in Parkinson Disease

机译：硫胺素在帕金森病中的有益作用

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Summary Parkinson disease ( PD ) is the second most common form of neurodegeneration among elderly individuals. PD is clinically characterized by tremors, rigidity, slowness of movement, and postural imbalance. In this paper, we review the evidence for an association between PD and thiamine. Interestingly, a significant association has been demonstrated between PD and low levels of serum thiamine, and thiamine supplements appear to have beneficial clinical effects against PD . Multiple studies have evaluated the connection between thiamine and PD pathology, and candidate pathways involve the transcription factor S p1, p53, B cl‐2, caspase‐3, tyrosine hydroxylase, glycogen synthase kinase‐3β, vascular endothelial growth factor, advanced glycation end products, nuclear factor kappa B , mitogen‐activated protein kinase, and the reduced form of nicotinamide adenine dinucleotide phosphate. Thus, a review of the literature suggests that thiamine plays a role in PD , although further investigation into the effects of thiamine in PD is needed.
机译：总结帕金森病（PD）是老年人中第二大最常见的神经退行性疾病。 PD的临床特征是震颤，僵硬，运动缓慢和姿势不平衡。在本文中，我们回顾了PD与硫胺素之间相关性的证据。有趣的是，已经证明PD与低水平的血清硫胺素之间存在显着关联，硫胺素补充剂似乎对PD具有有益的临床作用。多项研究评估了硫胺素与PD病理之间的联系，候选途径涉及转录因子S p1，p53，B cl-2，caspase-3，酪氨酸羟化酶，糖原合酶激酶-3β，血管内皮生长因子，晚期糖基化末端产品，核因子κB，促分裂原激活的蛋白激酶和烟酰胺腺嘌呤二核苷酸磷酸的还原形式。因此，尽管需要进一步研究硫胺素在PD中的作用，但文献综述表明硫胺素在PD中起着作用。

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