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首页> 外文期刊>CNS neuroscience & therapeutics. >Vascular Endothelial Growth Factor Gene Promoter Polymorphisms and Alzheimer's Disease Risk: A Meta‐Analysis
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Vascular Endothelial Growth Factor Gene Promoter Polymorphisms and Alzheimer's Disease Risk: A Meta‐Analysis

机译：血管内皮生长因子基因启动子多态性与阿尔茨海默氏病风险：荟萃分析

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Summary Aim Conclusions on the association between polymorphisms in the vascular endothelial growth factor ( VEGF ) gene promoter and risk of A lzheimer's disease ( AD ) are ambiguous, and sufficient evaluation of the association is lacking. Therefore, we performed a meta‐analysis of observational studies to explore the association between polymorphisms in the VEGF gene promoter and AD risk. Methods Bibliographical searches were performed in the MEDLINE , EMBASE , and C hina N ational K nowledge I nfrastructure ( CNKI ) databases without any language limitations. Three investigators independently assessed abstracts for relevant studies and independently reviewed all eligible studies. A meta‐analysis was conducted using a fixed‐ or random‐effects model. Odds ratios ( OR s) and their 95% confidence intervals ( CI s) were used to assess the strength of association. All statistical analyses were performed using Stata 11.0 software. Results The meta‐analysis of 2787 AD cases and 2841 controls from eight published case‐control studies on the ‐2578C/A polymorphism and 1422 AD cases and 1063 controls from four studies on the ‐1154G/A polymorphism did not show any significant associations. However, in a subgroup analysis stratified by the presence of APOE ?4 , associations were observed with APOE ε4 (‐) for ‐2578C/A (A vs. C: OR = 1.22, 95% CI = 1.04–1.43, P = 0.014; A/A vs. C/C: OR = 1.59, 95% CI = 1.11–2.27, P = 0.011 and A/A vs. A/C + C/C: OR = 1.46, 95% CI = 1.08–1.99, P = 0.015) and ‐1154G/A (A vs. G: OR = 0.74, 95% CI = 0.62–0.89, P = 0.001; A/A vs. G/G: OR = 0.57, 95% CI = 0.37–0.87, P = 0.009; A/G vs. G/G: OR = 0.69, 95% CI = 0.53–0.89, P = 0.004 and A/A + A/G vs. G/G: OR = 0.66, 95% CI = 0.52–0.85, P = 0.001). Conclusion This meta‐analysis showed the risk role of the ‐2578 polymorphism and the protective role of the ‐1154 polymorphism when the APOE ?4 status was negative, suggesting that the two polymorphisms in the VEGF promoter may have opposing effects on AD risk in an APOE ?4 ‐independent manner.
机译：概述目的关于血管内皮生长因子（VEGF）基因启动子多态性与阿兹海默氏病（AD）风险之间的关联的结论尚不明确，并且缺乏足够的关联性评估。因此，我们进行了一项观察性研究的荟萃分析，以探索VEGF基因启动子中的多态性与AD风险之间的关系。方法在MEDLINE，EMBASE和中国知识基础设施（CNKI）数据库中进行了书目搜索，没有任何语言限制。三名研究者独立评估了相关研究的摘要，并独立审查了所有符合条件的研究。荟萃分析使用固定或随机效应模型进行。奇数比（OR s）和其95％置信区间（CI s）用于评估关联强度。所有统计分析均使用Stata 11.0软件进行。结果对8项已发表的关于2578C / A多态性的病例对照研究中的2787例AD和2841例对照以及对于1154G / A多态性的四项研究中的1422例AD和1063对照的荟萃分析未显示任何显着相关性。但是，在以APOE？4存在为分层的亚组分析中，观察到‐2578C / A与APOEε4（-）有关联（A对C：OR = 1.22，95％CI = 1.04-1.43，P = 0.014 ; A / A与C / C：OR = 1.59，95％CI = 1.11–2.27，P = 0.011，A / A与A / C + C / C：OR = 1.46，95％CI = 1.08–1.99 ，P = 0.015）和-1154G / A（A vs. G：OR = 0.74，95％CI = 0.62-0.89，P = 0.001; A / A vs. G / G：OR = 0.57，95％CI = 0.37 –0.87，P = 0.009; A / G与G / G：OR = 0.69，95％CI = 0.53-0.89，P = 0.004，以及A / A + A / G与G / G：OR = 0.66，95 ％CI = 0.52-0.85，P = 0.001）。结论该荟萃分析显示，当APOEα4状态为阴性时，-2578基因多态性的风险作用和1154基因多态性的保护作用，提示VEGF启动子中的两个基因多态性可能对AD风险具有相反的影响。 APOE？4-独立方式。

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