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首页> 外文期刊>CNS neuroscience & therapeutics. >The Emerging Use of Ketamine for Anesthesia and Sedation in Traumatic Brain Injuries
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The Emerging Use of Ketamine for Anesthesia and Sedation in Traumatic Brain Injuries

机译：氯胺酮在创伤性脑损伤中的麻醉和镇静作用的新兴应用

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Summary Traditionally, the use of ketamine for patients with traumatic brain injuries is contraindicated due to the concern of increasing intracranial pressure ( ICP ). These concerns, however, originated from early studies and case reports that were inadequately controlled and designed. Recently, the concern of using ketamine in these patients has been challenged by a number of published studies demonstrating that the use of ketamine was safe in these patients. This article reviews the current literature in regards to using ketamine in patients with traumatic brain injuries in different clinical settings associated with anesthesia, as well as reviews the potential mechanisms underlying the neuroprotective effects of ketamine. Studies examining the use of ketamine for induction, maintenance, and sedation in patients with TBI have had promising results. The use of ketamine in a controlled ventilation setting and in combination with other sedative agents has demonstrated no increase in ICP . The role of ketamine as a neuroprotective agent in humans remains inconclusive and adequately powered; randomized controlled trials performed in patients undergoing surgery for traumatic brain injury are necessary.
机译：小结传统上，由于担心颅内压（ICP）升高，因此氯胺酮在颅脑外伤患者中的使用是禁忌的。但是，这些担忧源自对控制和设计不充分的早期研究和案例报告。最近，许多已发表的研究表明，在这些患者中使用氯胺酮已受到质疑，这些研究表明在这些患者中使用氯胺酮是安全的。本文回顾了有关在与麻醉有关的不同临床情况下在颅脑外伤患者中使用氯胺酮的最新文献，并综述了氯胺酮潜在的神经保护作用机制。研究氯胺酮在TBI患者中的诱导，维持和镇静作用的研究取得了可喜的结果。氯胺酮在受控的通风环境中的使用和与其他镇静剂的结合使用并没有证明ICP的增加。氯胺酮在人类中作为神经保护剂的作用尚无定论，并且作用足够。在接受颅脑外伤手术的患者中进行随机对照试验是必要的。

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