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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Establishing Phenotypic Features Associated with Morbidity in Human T-Cell Lymphotropic Virus Type 1 Infection
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Establishing Phenotypic Features Associated with Morbidity in Human T-Cell Lymphotropic Virus Type 1 Infection

机译：建立与人类T细胞淋巴病毒1型感染的发病率相关的表型特征

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The human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HT). Although it is widely believed that virus infection and host immune response are involved in the pathogenic mechanisms, the role of the immune system in the development and/or maintenance of HT remains unknown. We performed an analysis of the peripheral blood leukocyte phenotype for two different subcohorts of HTLV-1-infected individuals to verify the existence of similar immunological alterations, possible laboratory markers for HT. The leukocyte population balance, the activation status of the T lymphocytes, and the cellular migratory potential of T lymphocytes, monocytes, and neutrophils were evaluated in the peripheral blood of HTLV-1-infected individuals classified as asymptomatic individuals, oligosymptomatic individuals, and individuals with HT. Data analysis demonstrated that a decreased percentage of B cells, resulting in an increased T cell/B cell ratio and an increase in the CD8+ HLA-DR+ T lymphocytes, exclusively in the HT group could be identified in both subcohorts, suggesting its possible use as a potential immunological marker for HT for use in the laboratory. Moreover, analysis of likelihood ratios showed that if an HTLV-1-infected individual demonstrated B-cell percentages lower than 7.0%, a T cell/B cell ratio higher than 11, or a percentage of CD8+ HLA-DR+ T lymphocytes higher than 70.0%, this individual would have, respectively, a 12-, 13-, or 22-times-greater chance of belonging to the HT group. Based on these data, we propose that the T cell/B cell ratios and percentages of circulating B cells and activated CD8+ T lymphocytes in HTLV-1-infected patients are important immunological indicators which could help clinicians monitor HTLV-1 infection and differentiate the HT group from the asymptomatic and oligosymptomatic groups.
机译：1型人类T细胞淋巴病毒（HTLV-1）是与HTLV-1相关的脊髓病/热带痉挛性轻瘫（HT）的病原体。尽管普遍认为病毒感染和宿主免疫应答与致病机理有关，但是免疫系统在HT的发展和/或维持中的作用仍然未知。我们对HTLV-1感染个体的两个不同亚群进行了外周血白细胞表型分析，以验证是否存在相似的免疫学改变，可能是HT的实验室标志物。在被HTLV-1感染的无症状个体，少症状个体和有HBV感染的个体的外周血中评估白细胞种群平衡，T淋巴细胞的激活状态以及T淋巴细胞，单核细胞和中性粒细胞的细胞迁移潜力。 H T。数据分析表明，B细胞百分比降低，导致T细胞/ B细胞比率增加，而CD8 + HLA-DR + T淋巴细胞增多在这两个亚人群中均可以鉴定出HT组中的“三聚氰胺”，这表明它有可能用作实验室中潜在的HT免疫标记物。此外，可能性比分析显示，如果感染HTLV-1的个体的B细胞百分比低于7.0％，T细胞/ B细胞比例高于11，或者CD8 + 的百分比HLA-DR + T淋巴细胞高于70.0％，该人属于HT组的机会分别为12倍，13倍或22倍。基于这些数据，我们认为感染HTLV-1的患者的T细胞/ B细胞比例，循环B细胞百分比和活化的CD8 + T淋巴细胞百分比是重要的免疫学指标，有助于临床医生监测HTLV-1感染，将HT组与无症状和少症状组区别开来。

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