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Human T-cell lymphotropic virus type II envelope protein and human monoclonal antibodies specific therefor
Human T-cell lymphotropic virus type II envelope protein and human monoclonal antibodies specific therefor
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机译:人类T细胞淋巴病毒II型包膜蛋白及其特异性单克隆抗体
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摘要
Isolated and purified envelope protein of HTLV-I is provided devoid of non-envelope protein of HTLV-I and having substantially the same conformation as the envelope protein in native HTLV-I. The protein is produced recombinantly using a dual vaccinia/T7 polymerase system. Non-glycosylated and glycosylated forms of the protein are produced. Glycosylated forms are recognized by antibodies specific for the envelope protein of HTLV-I. Monoclonal antibodies are provided which are specific for the HTLV-I envelope protein and non-binding to HTLV-I envelope protein in denatured form. The HTLV-I envelope protein is cross-reactive with antibodies of HTLV-II and STLV. The envelope protein is useful in diagnosis of infection by HTLV-I and HTLV-II.
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