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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Effect of Pregnancy and Human Immunodeficiency Virus Infection on Intracellular Interleukin-2 Production Patterns
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Effect of Pregnancy and Human Immunodeficiency Virus Infection on Intracellular Interleukin-2 Production Patterns

机译：妊娠和人类免疫缺陷病毒感染对细胞内白介素2产生方式的影响

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Human immunodeficiency virus type 1 (HIV-1) infection decreases the production of interleukin-2 (IL-2) from CD4+ and CD8+ T cells. Recombinant IL-2 (rIl-2) has been given to HIV-infected individuals to generate significant increases in CD4+ T-cell counts. There are limited data regarding the effects of pregnancy and HIV infection on IL-2 production in humans. To investigate the effects of human pregnancy, HIV infection, and HIV therapy on IL-2 production, we evaluated 61 women. Intracellular IL-2 production by CD4+ T cells from nonpregnant HIV-infected women was significantly lower than in that in uninfected women (45% ± 8% versus 52% ± 8%, P = 0.04). In contrast, there was no difference in levels of intracellular IL-2 production between HIV-infected and uninfected pregnant women. These observations suggest that pregnancy may down-regulate IL-2 production regardless of HIV infection status. Future studies should evaluate IL-2 production patterns in larger cohorts of women so that the physiological significance of IL-2 down-regulation in pregnancy can be further evaluated. This information is essential to assess the possible use of IL-2 supplementation therapy as a means of enhancing immune responses among HIV-infected pregnant women.
机译：人类1型免疫缺陷病毒（HIV-1）感染会降低CD4 + 和CD8 + T细胞产生白介素2（IL-2）的能力。已将重组IL-2（rIl-2）用于HIV感染的个体，以使CD4 + T细胞计数显着增加。关于妊娠和HIV感染对人类IL-2产生的影响的数据有限。为了调查人类妊娠，HIV感染和HIV治疗对IL-2产生的影响，我们评估了61名妇女。未怀孕的HIV感染妇女的CD4 + T细胞产生的细胞内IL-2明显低于未感染妇女（45％±8％对52％±8％， P < / em> = 0.04）。相反，在HIV感染的孕妇和未感染的孕妇之间，细胞内IL-2的产生水平没有差异。这些观察结果表明，无论HIV感染状况如何，怀孕都可能下调IL-2的产生。未来的研究应评估较大人群妇女的IL-2产生方式，以便可以进一步评估孕妇IL-2下调的生理意义。此信息对于评估IL-2补充疗法作为增强HIV感染孕妇之间免疫反应的手段的可能性至关重要。

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