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首页> 外文期刊>Comparative Hepatology >CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis
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CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis

机译：CIDE-A在老年小鼠的肝脏和表现出脂肪变性的2型糖尿病小鼠肝脏中表达

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Background Increased levels of circulating fatty acids caused by insulin resistance and increased adipocyte lipolysis can accumulate within the liver resulting in steatosis. This steatosis sensitizes the liver to inflammation and further injury which can lead to liver dysfunction. We performed microarray analysis on normal mouse liver tissue at different ages and type 2 diabetic liver exhibiting steatosis to identify differentially expressed genes involved in lipid accumulation and liver dysfunction. Results Microarray analysis identified CIDE-A as the most differentially expressed gene as a function of age. Mice fed a high fat diet developed hyperinsulinemia, hyperglycemia and liver steatosis, all features of the human metabolic syndrome. Increased CIDE-A expression was observed in type 2 diabetic liver and the elevated CIDE-A expression could be reversed by weight loss and normalization of plasma insulin. Also, CIDE-A expression was found to be correlated with hepatic lipid accumulation. Conclusion The corresponding increase in CIDE-A expression with hyperinsulinemia and liver steatosis suggests a novel pathway for lipid accumulation in the liver.
机译：背景技术由胰岛素抵抗引起的循环脂肪酸水平增加和脂肪细胞脂解作用增加会在肝脏内积聚，从而导致脂肪变性。这种脂肪变性使肝脏对炎症和进一步的损伤敏感，这可能导致肝功能障碍。我们对不同年龄的正常小鼠肝脏组织和表现出脂肪变性的2型糖尿病肝脏进行了微阵列分析，以鉴定参与脂质蓄积和肝功能异常的差异表达基因。结果微阵列分析确定CIDE-A是随年龄变化的差异最大的基因。喂养高脂饮食的小鼠发展为高胰岛素血症，高血糖症和肝脂肪变性，这是人类代谢综合征的所有特征。在2型糖尿病肝脏中观察到CIDE-A表达增加，并且体重减轻和血浆胰岛素正常化可以逆转CIDE-A表达增加。另外，发现CIDE-A表达与肝脂质蓄积相关。结论高胰岛素血症和肝脂肪变性引起的CIDE-A表达相应增加，提示肝脏脂质蓄积的新途径。

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