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首页> 外文期刊>Clinical Medicine: Urology >In vitro Efficacy of Ureteral Catheters Impregnated with Ciprofloxacin, N-acetylcysteine and their Combinations on Microbial Adherence
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In vitro Efficacy of Ureteral Catheters Impregnated with Ciprofloxacin, N-acetylcysteine and their Combinations on Microbial Adherence

机译：环丙沙星，N-乙酰半胱氨酸浸渍输尿管导管及其组合对微生物黏附的体外功效

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Background: Ureteral catheters are valuable indispensable devices may readily acquire biofilms on the inner or outer surfaces. This study evaluated the efficacies of ureteral catheters impregnated with ciprofloxacin, N-acetylcysteine each alone and in combination on microbial adherence.Methods: Antimicrobial durability of ureteral catheters coated, through instant dip method, with ciprofloxacin were determined using modified Kirby-Bauer method. Ciprofloxacin-coated catheters showed zones of inhibition ranged from 15 to 45 mm in diameter (baseline) against nine clinical strains recently isolated from patients undergoing ureteral stent removal. Segments coated with ciprofloxacin, N-acetylcysteine each alone and in combination, through instant dip method, were incubated with the tested microorganisms, washed, sonicated, cultured and the number of viable cells were determined.Results: Ciprofloxacin-coated catheters soaked in urine and incubated at 37 °C, maintained antimicrobial activities and produce zones of inhibition that measured 2–10 mm for at least 8 weeks. Effect of ciprofloxacin and N-acetylcysteine coated catheters on microbial adherence were found to be dose dependent. Catheters impregnated with ciprofloxacin/N-acetylcysteine showed the highest inhibitory effect on microbial adherence when compared with controls (85.5%–100%).Conclusion: Catheters impregnated with ciprofloxacin, using instant dip method, were shown to have broad spectrum, prolonged antimicrobial durability and high efficacy. On the other hand, Catheters impregnated with ciprofloxacin/NAC showed the highest inhibitory effect on microbial adherence to stent surfaces.
机译：背景：输尿管导管是宝贵的必不可少的设备，可以很容易地在内表面或外表面上获得生物膜。本研究评估了单独或联合使用环丙沙星和N-乙酰半胱氨酸浸渍的输尿管导管对微生物粘附的有效性。方法：采用改良的Kirby-Bauer方法，通过即时浸涂法测定环丙沙星涂覆的输尿管的抗菌耐久性。环丙沙星涂层的导管显示出对最近从接受输尿管支架切除术的患者中分离出的九种临床菌株的抑制作用区域的直径范围（直径）为15至45 mm（基线）。分别用环丙沙星和N-乙酰半胱氨酸包被的段分别通过速溶法与被测试的微生物一起孵育，洗涤，超声处理，培养并确定活细胞的数量。结果：将环丙沙星包被的导管浸泡在尿液和尿液中。在37°C下温育，保持抗菌活性并产生至少8周的2-10 mm的抑制区域。发现环丙沙星和N-乙酰半胱氨酸涂层的导管对微生物粘附的影响是剂量依赖性的。与对照相比，浸渍有环丙沙星/ N-乙酰半胱氨酸的导管对微生物粘附的抑制作用最高（85.5％–100％）。结论：采用即时浸没法浸渍有环丙沙星的导管具有广谱性，延长了抗菌剂的耐久性和高功效。另一方面，用环丙沙星/ NAC浸渍的导管对微生物粘附到支架表面的抑制作用最高。

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