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首页> 外文期刊>Cureus. >Self-Reported Acalculia as a Presenting Symptom of Non-Dominant Right Parietal Glioblastoma Multiforme
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Self-Reported Acalculia as a Presenting Symptom of Non-Dominant Right Parietal Glioblastoma Multiforme

机译：自我报告的失语症作为非主要的右顶壁胶质母细胞瘤的表现症状。

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Acalculia, the acquired inability to perform simple mathematical operations, is classically associated with lesions to the left angular and supramarginal gyri. In this case report, we present a pair of right-handed patients whose presenting complaint was acalculia in the absence of finger agnosia, agraphia, or language deficit. Both patients had WHO grade IV glioblastoma multiforme tumors in the right superior parieto-occipital cortex. We hypothesize that the acalculia with abnormal tumor locale may be related to the way that these two individuals process mathematical problems. Both were extremely highly functioning - one being a university professor and the other a CEO of a financial institution. It is known that for many people simple mathematical operations are a function primarily of internal auditory recital and working memory, and in others, equations obey a type of sentence structure linked to the same cognitive mechanisms as writing. However, some individuals form internal spatial/structural diagrams for simple equations and solve mathematical solutions by spatial manipulation. We hypothesize that the high-functioning patients in our report shared a common mechanism for solving simple arithmetic problems, involving the spatial manipulation of mathematical objects in an internal space that is represented and manipulated in non-dominant right parietal cortex - and therefore their mathematical ability was disrupted by the invasion of tumor into this region and associated sequelae (tissue invasion, edema, mass effect).
机译：失语症是后天无法进行简单的数学运算，通常与左角和上指回的病变有关。在此病例报告中，我们介绍了一对惯用右手的患者，他们的主诉为失语，没有手指失明，失语或语言缺陷。两名患者的右上顶枕皮层均患有WHO IV级胶质母细胞瘤。我们假设具有异常肿瘤部位的失语症可能与这两个人处理数学问题的方式有关。两者都发挥着极高的作用-一个是大学教授，另一个是金融机构的首席执行官。众所周知，对于许多人而言，简单的数学运算主要是内部听觉独奏和工作记忆的函数，而在其他情况下，方程式则服从与写作相同的认知机制相关的一种句子结构。但是，有些人为简单的方程式形成内部空间/结构图，并通过空间操作来求解数学解。我们假设报告中的高功能患者共享解决简单算术问题的通用机制，涉及在内部空间中对数学对象的空间操作，该空间在非主要的右顶叶皮层中表示和操作-因此他们的数学能力被肿瘤侵入该区域和相关后遗症（组织浸润，水肿，质量效应）所破坏。

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