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首页> 外文期刊>Current Journal of Applied Science and Technology >Prevalence and Correlates of Major DepressiveDisorder among Human Immunodeficiency VirusInfected Adults in Sub-Saharan Africa: A SystematicReview and Meta-analysis
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Prevalence and Correlates of Major DepressiveDisorder among Human Immunodeficiency VirusInfected Adults in Sub-Saharan Africa: A SystematicReview and Meta-analysis

机译：撒哈拉以南非洲人类免疫缺陷病毒感染成年人中主要抑郁症的患病率及其相关性：系统评价和荟萃分析

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Introduction: Although major depressive disorder (MDD) is the commonest psychiatric complication of HIV infection, its prevalence and correlates are not fully evaluated in Sub-Saharan Africa (SSA).Methods: PsychInfo, Medline and Google scholar were among the data bases searched for relevant publications up to December 2013. Assessments of study quality, heterogeneity test ( I~(2) statistics) and sensitivity analysis were performed. We used random-effects model (REM) meta-analysis to derive pooled estimates of MDD in SSA. Statistically significant p-value in both Egger’s and Begg’s tests denote publication bias.Results: The prevalence (95% confidence interval [CI]) of MDD among HIV infected subjects was 17.3% (11.65-22.97). Symptomatic patients with Acquired immune deficiency syndrome (AIDS) had significantly higher prevalence than asymptomatic patients (17.5% and 8.3% respectively, P = .036). Odds Ratio [OR] (95% CI) of correlates of MDD were: HIV infection = 3.1 (1.97-4.17), female gender = 1.71 (1.09-2.32), Tuberculosis (TB) = 2.34 (1.0-5.63), food insecurity = 2.89 (1.40-5.89), higher income = 0.68 (0.45-1.0) and high social support = 0.75 (0.60-0.90).Conclusion: HIV infection is associated with development of MDD and AIDS patients are mostly afflicted. Preventing disease progression and improving the social welfare of patients are interventions needed to reduce the burden of MDD among HIV-infected subjects in SSA.
机译：简介：尽管重性抑郁症（MDD）是艾滋病毒感染最常见的精神病并发症，但在撒哈拉以南非洲（SSA）中，其患病率和相关性尚未得到充分评估。直至2013年12月的相关出版物。进行了研究质量，异质性测试（I〜（2）统计）和敏感性分析的评估。我们使用随机效应模型（REM）荟萃分析得出SSA中MDD的汇总估计。 Egger检验和Begg检验均具有统计学意义的p值表示发表偏倚。结果：HIV感染者中MDD的患病率（95％置信区间[CI]）为17.3％（11.65-22.97）。有症状的获得性免疫缺陷综合征（AIDS）患者的患病率明显高于无症状的患者（分别为17.5％和8.3％，P = .036）。与MDD相关的几率[OR]（95％CI）为：HIV感染= 3.1（1.97-4.17），女性= 1.71（1.09-2.32），肺结核（TB）= 2.34（1.0-5.63），粮食不安全= 2.89（1.40-5.89），较高的收入= 0.68（0.45-1.0）和较高的社会支持= 0.75（0.60-0.90）。结论：HIV感染与MDD的发展有关，而AIDS患者多数是受累的。预防疾病进展和改善患者的社会福利是减少SSA中HIV感染者中MDD负担所需的干预措施。

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