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首页> 外文期刊>Cureus. >Cerebrospinal Fluid Total Tau is Increased in Normal Pressure Hydrocephalus Patients who Undergo Successful Lumbar Drain Trials
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Cerebrospinal Fluid Total Tau is Increased in Normal Pressure Hydrocephalus Patients who Undergo Successful Lumbar Drain Trials

机译：在成功进行腰椎引流​​试验的常压脑积水患者中，脑脊液总Tau升高

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Background Idiopathic normal pressure hydrocephalus (INPH) is a neurologic disease that affects 65 years, but is difficult to distinguish from other diseases that present in this age group, such as Alzheimer’s disease. Large volume lumbar puncture and an external lumbar drain trial (ELD) are used to make a clinical diagnosis of INPH, but the accuracy of ELD is suspected. Objective To investigate proteomic cerebrospinal fluid (CSF) biomarker patterns in patients with INPH undergoing ELD to develop a quantitative diagnostic. Methods Twenty patients with suspected INPH underwent an ELD trial and the CSF biomarkers ABsub1-42/sub, total tau, and tau phosphorylated at amino acid 181 (p-tau) were quantified with immunoassays in specimens taken prior to ELD placement, after the ELD trial, and from ventricular samples collected at the time of permanent ventriculoperitoneal shunt placement. Results CSF total tau was elevated, on average, in pre- and post-ELD samples from patients who failed to improve clinically during the ELD trial, but the findings were marginally significant after correction for multiple comparisons. ABsub1-42 /suband p-tau concentrations were not significantly different in patients who either did or did not clinically improve after the ELD. Conclusions CSF total tau is a potential novel biomarker for suspected INPH patients who will clinically improve, or have clinically improved, after an ELD trial. The small sample size of this study, which was due to the relative rarity of this condition, indicates that larger studies are needed to confirm the utility of this approach.
机译：背景特发性常压脑积水（INPH）是一种影响65岁的神经系统疾病，但很难与该年龄段的其他疾病（例如阿尔茨海默氏病）区分开。大体积腰穿术和外部腰椎引流试验（ELD）用于进行INPH的临床诊断，但怀疑ELD的准确性。目的探讨INPH行ELD患者的蛋白质组学脑脊液（CSF）生物标志物模式，以建立定量诊断方法。方法对20名怀疑INPH的患者进行了ELD试验，并用免疫分析的方法对20例之前采集的标本中的CSF生物标志物AB 1-42 ，总tau和磷酸181位（p-tau）磷酸化的tau进行了测定。 ELD试验后进行的ELD放置，以及永久性腹膜-腹膜分流放置时收集的心室样本。结果在ELD试验期间，在临床上未能改善的患者的ELD前后，平均CSF总tau升高，但经过多次比较校正后，发现的意义很小。 ELD后临床改善或未改善的患者中AB 1-42 和p-tau浓度无显着差异。结论CSF总tau是可疑的INPH患者的一种潜在的新型生物标志物，这些患者在ELD试验后将临床改善或已经改善。由于这种情况相对罕见，因此本研究的样本量较小，表明需要进行大量研究才能证实这种方法的实用性。

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