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首页> 外文期刊>Acta Cirurgica Brasileira >Effects of blocking αvβ3 integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats
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Effects of blocking αvβ3 integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats

机译：重组RGD双整合素阻断αvβ3整合素对大鼠切口疝诱导后伤口愈合重塑的影响

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PURPOSE: To investigate the changes induced by DisBa-01 on repair of wound healing after induced incisional hernia (IH) in rats. METHODS: Thirty two male albino rats were submitted to IH and divided into four experimental groups: G1, placebo control; G2, DisBa-01-treated; G3, anti-αvβ3 antibodies-treated and G4, anti-α2 antibodies-treated. Histological, biochemical and extracellular matrix remodeling analysis of abdominal wall were evaluated. RESULTS: After 14 days, 100% of the G2 did not present hernia, and the hernia ring was closed by a thin membrane. In contrast, all groups maintained incisional hernia. DisBa-01 also increased the number macrophages and fibroblasts and induced the formation of new vessels. Additionally, MMP-2 was strongly activated only in G2 (p0.05). Anti- αvβ3-integrin antibodies produced similar results than DisBa-01 but not anti-α2 integrin blocking antibodies. CONCLUSION: DisBa-01 has an important role in the control of wound healing and the blocking of this integrin may be an interesting therapeutically strategy in incisional hernia.
机译：目的：探讨DisBa-01诱导的大鼠切开性疝（IH）术后修复伤口愈合的变化。方法：将32只白化病雄性大鼠送入IH，分为4个实验组：G1组，安慰剂对照组，G1组，安慰剂对照组。 G2，DisBa-01处理; G3，抗αvβ3抗体处理过，G4，抗α2抗体处理过。评估了腹壁的组织学，生化和细胞外基质重塑分析。结果：14天后，100％的G2未出现疝气，疝气环被薄膜封闭。相反，所有组均保持切口疝。 DisBa-01还增加了巨噬细胞和成纤维细胞的数量，并诱导了新血管的形成。此外，MMP-2仅在G2中被强烈激活（p <0.05）。抗αvβ3整合素抗体产生的结果与DisBa-01类似，但抗α2整合素阻断抗体产生的结果不同。结论：DisBa-01在控制伤口愈合中起着重要作用，而这种整联蛋白的阻断可能是切开疝的一种有趣的治疗策略。

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