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首页> 外文期刊>Acta histochemica et cytochemica. >Involvement of 4-hydroxy-2-nonenal Accumulation in Multiple System Atrophy
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Involvement of 4-hydroxy-2-nonenal Accumulation in Multiple System Atrophy

机译：4-羟基-2-壬烯积累参与多系统萎缩。

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Recent studies have suggested implications for α-synuclein cytotoxicity in the pathomechanism of multiple system atrophy (MSA). Given in vitro evidence that α-synuclein generates oxidative stress, it is proposed that lipid peroxidation may be accelerated in MSA. To address this issue, we performed an immunohistochemical analysis of protein-bound 4-hydroxy-2-nonenal (P-HNE) in sections of archival, formalin-fixed, paraffin-embedded pontine materials of eight sporadic MSA patients and eight age-matched control subjects. In the MSA cases, P-HNE immunoreactivity was localized in all of the neuronal cytoplasmic inclusions and glial cytoplasmic inclusions, both of them identified with α-synuclein and ubiquitin. It was also detectable in reactive astrocytes and phagocytic microglia but undetectable in activated microglia. By contrast, P-HNE immunoreactivity in the control cases was only very weak or not at all in the parenchyma including neurons and glia. The present results provide in vivo evidence that HNE participates in α-synuclein-induced cytotoxicity and neuroinflammation in MSA.
机译：最近的研究表明，α-突触核蛋白的细胞毒性在多系统萎缩（MSA）的发病机制中具有重要意义。鉴于体外证据表明α-突触核蛋白会产生氧化应激，建议在MSA中可加速脂质过氧化。为了解决这个问题，我们对八名散发性MSA患者和八名年龄相匹配的档案进行了福尔马林固定，石蜡包埋的桥脑材料存档部分中的蛋白质结合的4-羟基-2-壬烯（P-HNE）免疫组织化学分析。控制对象。在MSA病例中，P-HNE免疫反应性位于所有神经元细胞质包涵体和神经胶质细胞质包涵体中，它们均由α-突触核蛋白和泛素鉴定。在反应性星形胶质细胞和吞噬小胶质细胞中也可检测到，但在活化的小胶质细胞中则未检测到。相比之下，在对照组中，包括神经元和神经胶质在内的实质组织中的P-HNE免疫反应性非常弱或完全没有。本结果提供了体内证据，表明HNE参与了MSA中α-突触核蛋白诱导的细胞毒性和神经炎症。

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