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首页> 外文期刊>Acta medica Okayama >Slow Fetal Heart Rate before Miscarriage in the Early First Trimester Predicts Fetal Aneuploidy in Women with Recurrent Pregnancy Loss
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Slow Fetal Heart Rate before Miscarriage in the Early First Trimester Predicts Fetal Aneuploidy in Women with Recurrent Pregnancy Loss

机译：早孕早期流产前胎儿心率缓慢可预测复发性流产女性的胎儿非整倍性。

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Establishing whether miscarriages result from fetal aneuploidy or other factors is important for treating recurrent pregnancy loss. We examined the relationship between fetal heart rate (FHR) before miscarriage in the early first trimester and fetal karyotype, analyzing 223 pregnant women with recurrent pregnancy loss. Among the pregnancies, 110 resulted in live births regarded as normal karyotype (the Norm-group). The other 113 pregnancies ended in miscarriage, and we categorized them into groups based on fetal karyotype, determined by chorionic villus sampling: the Misc-NK (normal karyotype) group, n=35 euploid cases; the Misc-CA1 (chromosomal abnormality) group, n=18 cases of aneuploidy with trisomies 13/18/21, Turner’s syndrome, or Klinefelter’s syndrome; and the Misc-CA2 subgroup, n=60 cases of other aneuploidies excluding those in the Misc-CA1 group. We compared the groups’ regression line slopes and intercepts for FHR by an analysis of covariance. The FHRs of the Norm, Misc-NK and Misc-CA1 groups increased from 36 to 49 days after fertilization, but did not significantly differ across these groups. The Misc-CA2 group’s FHR did not increase and significantly differed from the other three groups (p0.01). These results suggest that the absence of an increase in FHR in early pregnancy may indicate the presence of chromosomal abnormalities causing miscarriage.
机译：确定是否由胎儿非整倍性或其他因素引起的流产对于治疗复发性流产很重要。我们检查了早孕早期流产前的胎儿心率（FHR）与胎儿核型之间的关系，分析了223名反复流产的孕妇。在怀孕中，有110例活产被认为是正常的核型（正常组）。其他113例妊娠以流产结束，我们根据绒毛膜绒毛取样确定的胎儿核型将其分为几类：Misc-NK（正常核型）组，n = 35整倍体病例; Misc-CA1（染色体异常）组，n = 18非整倍性，伴三体性13/18/21，特纳氏综合征或克氏综合征;以及Misc-CA2亚组，n = 60例其他非整倍性，不包括Misc-CA1组。通过协方差分析，我们比较了各组的FHR回归线斜率和截距。受精后，Norm，Misc-NK和Misc-CA1组的FHR从36天增加到49天，但在这些组之间没有显着差异。 Misc-CA2组的FHR没有增加，并且与其他三组明显不同（p <0.01）。这些结果表明，妊娠早期FHR的升高可能表明存在导致流产的染色体异常。

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