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首页> 外文期刊>Acta medica Iranica. >Seroprevalence and risk factors of hepatitis delta virus in chronic hepatitis B virus infection in Zahedan.
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Seroprevalence and risk factors of hepatitis delta virus in chronic hepatitis B virus infection in Zahedan.

机译：扎赫丹市慢性乙型肝炎病毒感染中丙型肝炎三角洲病毒的血清阳性率和危险因素。

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Hepatitis delta virus (HDV) infection results in more severe and even fulminant form of hepatitis B in co-infected cases. This study was designed to estimate the prevalence of anti-HDV positivity and the associated risk factors in patients with chronic hepatitis B virus infection in Zahedan (Iran). In this cross-sectional study a total of 440 consecutive patients with chronic hepatitis B virus (HBV) infection attending the Zahedan Gastroenterology and Hepatology clinics from 2008 to 2011 were included. We performed test for HDV serum marker, using commercially available enzyme-linked immunosorbent assay kit. Patients were split into two groups according to their HDV antibody status as HDV positive or negative. The collected data were coded, and the statistical analyses were conducted. Four hundred and forty patients with various forms of chronic HBV-related liver diseases enrolled in the study. 200 (45.5%) patients were carrier for HBV. 196 (44.5%) patients had chronic active hepatitis and 44 (10%) patients suffered from cirrhosis. Anti-HDV was demonstrated in 75 patients (17%). The prevalence of HDV was 7%, 16.3% and 65.9% in carriers, patients with chronic active hepatitis and cirrhosis, respectively. HDV infection is still an important public health problem in Zahedan and appears a major cause of progression of liver disease induced by HBV.
机译：在合并感染的病例中，三角洲肝炎病毒（HDV）感染会导致更严重甚至暴发的乙型肝炎。这项研究旨在评估Zahedan（伊朗）慢性乙型肝炎病毒感染患者的抗HDV阳性率及其相关危险因素。在这项横断面研究中，纳入了2008年至2011年间在Zahedan胃肠病和肝病门诊就诊的440例慢性乙型肝炎病毒（HBV）感染患者。我们使用市售的酶联免疫吸附测定试剂盒对HDV血清标志物进行了测试。根据患者的HDV抗体状态分为HDV阳性或阴性，将其分为两组。对收集的数据进行编码，然后进行统计分析。 440名患有各种形式的慢性HBV相关肝病的患者参加了研究。 200（45.5％）名患者携带HBV。 196例（44.5％）患有慢性活动性肝炎，44例（10％）患有肝硬化。在75例患者中证明了抗HDV（17％）。携带者，慢性活动性肝炎和肝硬化患者的HDV患病率分别为7％，16.3％和65.9％。 HDV感染仍然是Zahedan的重要公共卫生问题，并且似乎是HBV诱发肝病进展的主要原因。

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