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首页> 外文期刊>Acta neurobiologiae experimentalis >Effects of post-weaning social isolation and environment al enrichment on exploratory behavior and ankiety in Wistar rats
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Effects of post-weaning social isolation and environment al enrichment on exploratory behavior and ankiety in Wistar rats

机译：断奶后社交孤立和环境充实对Wistar大鼠探索行为和焦虑的影响

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摘要

Adverse early experience is generally regarded as a risk factor for both externalizing and internalizing behavioral disorders in humans. It can be modeled in rats by a post-weaning social isolation procedure. Effects of social isolation might possibly be ameliorated by environmental enrichment. In the current study, 24 male Wistar rats were divided post-weaning into four rearing conditions: control, environmental enrichment (EE), social isolation (SI) and a combination of the two experimental conditions; (EE+SI). Two observations of the effects of rearing conditions on the rate of social and object interactions were conducted during the juvenile and post-pubertal stages of development. The SI condition led to a marked increase of social interactions during the juvenile phase, but did not affect object interactions. The EE condition increased the level of social interactions during both the juvenile and post-pubertal measurements. The effects of early rearing conditions on adult exploratory behavior were less clear, with a significant difference between the groups obtained in one of three behavioral tests. Results suggest a general robustness in the development of adult exploratory behavior and anxiety when rats were exposed to early social isolation and provided brief opportunities for social play during the juvenile period. Further studies, aimed at distinguishing play-related protective factors serving against long-term adverse effects of juvenile social isolation, are suggested.
机译：不良的早期经历通常被认为是人类行为失常的一种外在和内在化的危险因素。可以通过断奶后的社交隔离程序对大鼠进行建模。环境的丰富化可能会改善社会孤立的影响。在本研究中，将24只雄性Wistar大鼠断奶后分为四个饲养条件：对照，环境富集（EE），社会隔离（SI）以及这两个实验条件的组合。 （EE + SI）。在青少年期和青春期后阶段，对饲养条件对社交和对象互动率的影响进行了两项观察。 SI条件导致了少年时期社交互动的显着增加，但并未影响对象互动。在青少年和青春期测量后，EE状况增加了社交互动的水平。早期养育条件对成人探索行为的影响尚不清楚，在三种行为测试之一中，两组之间存在显着差异。结果表明，当大鼠暴露于早期的社会隔离中并为少年时期的社交活动提供了短暂的机会时，其对成人探索行为和焦虑的发展普遍具有鲁棒性。建议进行进一步的研究，以区分与玩耍相关的保护因素，以防止青少年社会孤立的长期不利影响。

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