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首页> 外文期刊>Acta neurobiologiae experimentalis >Nucleus accumbens local field potential power spectrums, phase-amplitude couplings and coherences following morphine treatment
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Nucleus accumbens local field potential power spectrums, phase-amplitude couplings and coherences following morphine treatment

机译：吗啡处理后伏伏核的局部场势能谱，相幅耦合和相干性

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In the past decade, neural processing has been extensively studied in cognitive neuroscience. However, neural signaling in thenucleus accumbens (NAc) that might clarify reward process remained to be investigated. Male Swiss albino ICR mice implanted withintracranial electrodes into the NAc and the ventral tegmental area (VTA) were used for morphine administration and local field potential (LFP) recording. One?way ANOVA revealed significant increases in low (30.3–44.9 Hz) and high (60.5–95.7 Hz) gamma powers in the NAc following morphine administration (5 and 15 mg/kg, i.p.). These gamma activities oscillated independently with different time?course responses. Locomotor activity was also significantly increased by morphine administration. Regression analyses revealed that high gamma activity induced by morphine was positively correlated with distance travelled by animals. Low and high gamma powers were completely abolished by injection of naloxone, a non?specific opiate antagonist. Analysis of phase?amplitude coupling confirmed that slow oscillations at 1–4 Hz (delta) and 4–8 Hz (theta) for phase were found to significantly increase modulation index of broad (30.27–80.77 Hz) and narrow (59.48–70.34 Hz) frequency ranges for amplitude, respectively. Moreover, significant increases in coherence values between the NAc and the VTA during 30–40 min following morphine administration were seen for22.46–44.90 Hz frequency range. Altogether, this study demonstrated changes of LFP oscillations in the NAc with low and high gamma activities, delta? and theta?gamma couplings and interplay with VTA in response to morphine administration. These findings represent neural signaling in the mesolimbic dopamine pathway that might process reward function.
机译：在过去的十年中，在认知神经科学中对神经处理进行了广泛的研究。然而，伏隔核（NAc）中可能澄清奖励过程的神经信号仍有待研究。将雄性瑞士白化ICR小鼠植入颅内电极至NAc和腹侧被盖区（VTA）中，用于吗啡给药和局部场电位（LFP）记录。单向方差分析显示吗啡给药后（5和15 mg / kg，腹腔注射），NAc中的低（30.3–44.9 Hz）和高（60.5–95.7 Hz）γ功率显着增加。这些伽马活动随不同的时程响应而独立地振荡。通过服用吗啡还可以显着提高运动能力。回归分析表明，吗啡诱导的高伽马活性与动物的行进距离呈正相关。纳洛酮是一种非特异性的阿片拮抗剂，完全消除了低和高伽马放大率。相振幅耦合分析证实，发现相位在1–4 Hz（δ）和4–8 Hz（θ）处的缓慢振荡会显着提高宽（30.27–80.77 Hz）和窄（59.48–70.34 Hz）的调制指数）的幅度幅度范围。此外，在22.46–44.90 Hz频率范围内，吗啡给药后30–40分钟内，NAc和VTA之间的相干值显着增加。总的来说，这项研究证明了低和高伽马活性的NAc中LFP振荡的变化，δ？和吗啡的耦合以及与VTA的相互作用对吗啡的反应。这些发现代表中脑边缘多巴胺途径中的神经信号传导，可能处理奖励功能。

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