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外文期刊>Acta neurobiologiae experimentalis
>Fos immunoreactivity in the intermediolateral nucleusinduced by tendon vibration of the m. triceps surae inrats pretreated with a nitric oxide blocker or precursor
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Fos immunoreactivity in the intermediolateral nucleusinduced by tendon vibration of the m. triceps surae inrats pretreated with a nitric oxide blocker or precursor
We investigated neuronal activation of the rat intermediolateral (IML) nucleus of the thoracolumbar spinal cord, initiated by Achillestendon vibration, after intramuscular (m. triceps surae) administration of 7.nitroindazole (7.NI) or L.arginine (LA). The spindle afferentresponse to vibratory stimuli induced a distinct bilateral increase in the activation of c.Fos immunoreactivity in the spinal neurons inthree groups of rats (tendon.vibrated, tendon.vibrated + 7.NI and tendon.vibrated + LA). The T5/T13 segments in tendon.vibrated+7.NI animals showed the highest increase of Fos.immunoreactive neurons. This increase was two times higher than that in tendononly.vibrated control rats and tendon.vibrated + LA animals. The highest mean number of labelled neurons were observed in theIML nucleus and in layers 4 and 7 of the T5-L3 segments in tendon.vibrated and tendon.vibrated + 7.NI animals, and in the IMLnucleus and layer 4 in tendon.vibrated + LA rats. The highest mean number of activated neurons was found ipsilaterally in the IMLnucleus of the T5/T13 segment. These results indicate that decreased nitric oxide release after injection of 7.NI was accompanied bya potentiation of the early c.fos gene expression induced by muscle proprioceptive activity within the thoracolumbar region of therat spinal cord. Thus, enhanced c.Fos immunoreactivity in the IML nucleus indicated that the sympathetic nervous system can exerta direct influence on the muscle spindles.
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