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首页> 外文期刊>Acta neurobiologiae experimentalis >Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor
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Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

机译：肌腱振动诱导的中期核中的FOS免疫反应性。 用一氧化氮阻断剂或前体预处理的大鼠肱三头肌surae

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摘要

We investigated neuronal activation of the rat intermediolateral (IML) nucleus of the thoracolumbar spinal cord, initiated by Achilles tendon vibration, after intramuscular (m. triceps surae) administration of 7-nitroindazole (7-NI) or L-arginine (LA). The spindle afferent response to vibratory stimuli induced a distinct bilateral increase in the activation of c-Fos immunoreactivity in the spinal neurons in three groups of rats (tendon-vibrated, tendon-vibrated + 7-NI and tendon-vibrated + LA). The T5/T13 segments in tendon-vibrated +7-NI animals showed the highest increase of Fos-immunoreactive neurons. This increase was two times higher than that in tendon only-vibrated control rats and tendon-vibrated + LA animals. The highest mean number of labelled neurons were observed in the IML nucleus and in layers 4 and 7 of the T5-L3 segments in tendon-vibrated and tendon-vibrated + 7-NI animals, and in the IML nucleus and layer 4 in tendon-vibrated + LA rats. The highest mean number of activated neurons was found ipsilaterally in the IML nucleus of the T5/T13 segment. These results indicate that decreased nitric oxide release after injection of 7-NI was accompanied by a potentiation of the early c-fos gene expression induced by muscle proprioceptive activity within the thoracolumbar region of the rat spinal cord. Thus, enhanced c-Fos immunoreactivity in the IML nucleus indicated that the sympathetic nervous system can exert a direct influence on the muscle spindles.
机译：我们研究了胸腔肌腱脊髓的大鼠中间体（IML）核的神经元激活，由Achilles肌腱振动，肌肉内肌腱振动引发，在肌肉内（肱三头肌SURAE）给药7-硝基吲唑（7- Ni）或L-精氨酸（La）。对振动刺激的主轴响应诱导了三组大鼠脊髓神经元中C-FOS免疫反应性的不同的双侧增加（肌腱振动，肌腱振动+ 7-Ni和肌腱振动+ 1a）。肌腱振动+ 7-Ni动物中的T5 / T13段显示出FOS-免疫反应性神经元的最高增加。这种增加比肌腱仅振动对照大鼠和肌腱振动+ La动物高两倍。在IML核和T5-L3区段的IML核和肌腱振动+ 7-Ni动物的T5-L3区段的层4和7中观察到最高平均标记的神经元，并在IML核和肌腱层4中振动+ la大鼠。在T5 / T13区段的IML核中发现最高的活化神经元的平均数量。这些结果表明，注射7-Ni后的一氧化氮释放减少伴随着通过大鼠脊髓的胸廓瘤区域内的肌肉癌症活性诱导的早期C-FOS基因表达的增强。因此，IML核中的增强的C-FOS免疫反应性表明，交感神经系统可以对肌肉纺锤进行直接影响。

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