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首页> 外文期刊>Acta Scientiarum : Biological Sciences >Polysaccharide extract of Mimosa tenuiflora stem barks stimulates acute inflammatory response via nitric oxide
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Polysaccharide extract of Mimosa tenuiflora stem barks stimulates acute inflammatory response via nitric oxide

机译：含羞草茎皮多糖提取物通过一氧化氮刺激急性炎症反应

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摘要

Mimosa tenuiflora (Mimosaceae) or “jurema-preta” is well distributed in the northeast Brazil, being popularly used to treat skin lesions, burns and inflammation. The healing effect of the alcoholic extract prepared with its barks corroborates the popular use. This study aimed to evaluate the inflammatory response of polysaccharides extracted from M. tenuiflora barks (EP-Mt) by methanol/NaOH and ethanol precipitation. Inflammatory activity was assessed in rat models of acute inflammation (paw edema and peritonitis), by the following parameters: edema, vascular permeability, leukocyte migration, myeloperoxidase activity and pharmacological modulation of nitric oxide and prostaglandins. EP-Mt presented 3.8% yield, 41% carbohydrate and 0.34% protein. EP-Mt (0.01, 0.1, 1.0 mg kg-1) injected by subcutaneous route elicited paw edema that lasted from 30-420 min, with maximal effect at 1 mg kg-1 (40x vs. saline), and was inhibited by L-NAME (52%) and dexamethasone (26%). EP-Mt (1 mg kg-1, via intraperitoneal) stimulated leukocytes migration (2.2x), mainly neutrophils (6.5x) and MPO activity (96%). The leukocyte migration elicited by EP-Mt was inhibited by dexamethasone (39%) and L-NAME (38%). EP-Mt containing high carbohydrate content induces acute inflammation via nitric oxide, which open perspectives of application in pathological conditions of immunosuppression.
机译：含羞草（Mimosaceae）或“朱雀花（Jerema-preta）”分布在巴西东北部，广泛用于治疗皮肤病变，烧伤和炎症。用其树皮制备的酒精提取物的治疗效果证实了其广泛的用途。这项研究旨在评估甲醇/氢氧化钠和乙醇沉淀从藤蔓皮（EP-Mt）提取的多糖的炎症反应。通过以下参数在急性炎症（爪水肿和腹膜炎）大鼠模型中评估炎症活性：水肿，血管通透性，白细胞迁移，髓过氧化物酶活性以及一氧化氮和前列腺素的药理学调节。 EP-Mt的收率为3.8％，碳水化合物为41％，蛋白质为0.34％。皮下注射的EP-Mt（0.01，0.1，1.0 mg kg-1）引起足爪水肿，持续30-420分钟，在1 mg kg-1时效果最大（40倍于生理盐水），并被L抑制-NAME（52％）和地塞米松（26％）。 EP-Mt（1 mg kg-1，通过腹膜内）刺激白细胞迁移（2.2倍），主要是中性粒细胞（6.5倍）和MPO活性（96％）。地塞米松（39％）和L-NAME（38％）抑制了EP-Mt引起的白细胞迁移。包含高碳水化合物含量的EP-Mt通过一氧化氮诱导急性炎症，这为在免疫抑制的病理条件下应用开辟了前景。

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