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首页> 外文期刊>Advances in Biological Chemistry >Cell Proliferation Inhibition by Sericin from the Wild Silkworm, Cricula trifenestrata
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Cell Proliferation Inhibition by Sericin from the Wild Silkworm, Cricula trifenestrata

机译：丝胶对野生家蚕Cricula trifenestrata的细胞增殖抑制作用

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Sericin is a major silk protein, and recent studies have shown that sericin has numerous physiological activities against cultured cells. For example, it accelerates mammalian cell proliferation and protects insect cells against cell death. In this study, we examined the activities of sericin prepared from the wild silkworm, Cricula trifenestrata. The results presented here indicated that C. trifenestrata sericin has anti-proliferative activity against feline kidney cells, while sericin from Bombyx mori promoted cell proliferation. The components of the sericin preparation that played a role in inhibition of proliferation were analyzed by fractionation through partition chromatography (Folch method) and reversed-phase chromatography. Our analysis showed that at least two components in the C. trifenestrata sericin preparation promoted the anti-proliferative activity in an additive or even synergistic manner. Therefore, differences in components between insect species may contribute to different activities against cultured cells.
机译：丝胶蛋白是一种主要的丝蛋白，最近的研究表明，丝胶蛋白对培养细胞具有多种生理活性。例如，它可以加速哺乳动物细胞的增殖并保护昆虫细胞免于细胞死亡。在这项研究中，我们检查了从野生蚕Cricula trifenestrata制备的丝胶蛋白的活性。此处显示的结果表明，C。trifenestrata丝胶具有抗猫肾细胞增殖的活性，而家蚕丝胶则促进细胞增殖。通过分配色谱法（Folch法）和反相色谱法分级分离来分析在抑制增殖中起作用的丝胶蛋白制剂的组分。我们的分析表明，三分线虫丝胶蛋白制剂中的至少两种成分以累加或什至协同的方式促进了抗增殖活性。因此，昆虫种类之间的成分差异可能会导致针对培养细胞的不同活性。

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