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首页> 外文期刊>Advances in Bioscience and Clinical Medicine >Effect of Diabetes Mellitus Type II on Long Bones Fractures Healing
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Effect of Diabetes Mellitus Type II on Long Bones Fractures Healing

机译：II型糖尿病对长骨骨折愈合的影响

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Introduction: Fracture healing is a complex process where synthesis and activation of a cascade of cells and molecules collaborate and participate in regeneration of the fractured bones. There are several factors involved in nonunion of fractured bones. Endocrine and metabolic diseases are regarded as factors causing nonunion of fractured bones. The present study aims at evaluating effect of diabetes type II, as an important and prevalent metabolic disease, on results of surgical treatment of long bones fractures. Method: This case-control study was conducted on 74 patients with isolated fracture of tibia and femur shafts resulting from low-energy trauma. In this study, 50 patients with definite diagnosis of diabetes were compared with 24 metabolically health persons considering age, gender, type of fracture, and treatment method. The diabetic patients were classified in two groups considering their insulin or oral agent. Level of hs-CRP inflammatory marker was also determined in these patients. Union rate and duration as well as relation between inflammatory marker and union rate were studied. Results: Prevalence of nonunion and delayed union were seen in 8 (32%) and 2 (8%) patients with orally-treated diabetes, respectively. It was 3 (12%) in diabetes patients treated with insulin. However, there was not any case of nonunion in the health group. There was a statistically significant difference between these groups. According to the regression model, hs-CRP level played a significant role considering nonunion prediction (P=0.001, Odd’s Ratio=3.4, CI95%:1.4-4.8). Also, type of diabetes treatment had a significant role in predicting nonunion (P=0.04, Odd’s Ratio=0.6, CI95%:0.3-1.4). Duration of being affected by diabetes did not play any important role in nonunion prediction. Conclusion: Prevalence of nonunion in patients with diabetes suffering from fracture and undergoing orthopedic surgery is higher than healthy people. It seems that increase of inflammatory markers and oral agents therapy plays an important role in causing and predicting of nonunion in these patients.
机译：简介：骨折愈合是一个复杂的过程，其中级联的细胞和分子的合成和激活相互配合并参与骨折骨骼的再生。骨折的骨头不愈合涉及多个因素。内分泌和代谢疾病被认为是导致骨折骨不愈合的因素。本研究旨在评估作为重要且流行的代谢疾病的II型糖尿病对长骨骨折的外科治疗效果。方法：本病例对照研究针对74例因低能量创伤导致的孤立性胫骨和股骨干骨折的患者。在这项研究中，根据年龄，性别，骨折类型和治疗方法，将50例确诊为糖尿病的患者与24名代谢健康患者进行了比较。考虑到他们的胰岛素或口服药物，将糖尿病患者分为两组。在这些患者中还测定了hs-CRP炎症标记物的水平。研究了联合率和持续时间，以及炎症标志物和联合率之间的关系。结果：分别在8例（32％）和2例（8％）的口服糖尿病患者中发现骨不连和延迟愈合的发生率。在接受胰岛素治疗的糖尿病患者中，这一比例为3（12％）。但是，卫生组中没有任何不愈合的情况。这些组之间在统计学上有显着差异。根据回归模型，考虑到骨不连预测，hs-CRP水平起着重要作用（P = 0.001，奇数比= 3.4，CI95％：1.4-4.8）。同样，糖尿病治疗的类型在预测骨不连方面也具有重要作用（P = 0.04，奇数比= 0.6，CI95％：0.3-1.4）。受糖尿病影响的持续时间在骨不连预测中没有任何重要作用。结论：患有骨折并接受骨科手术的糖尿病患者的骨不连发生率高于健康人。炎症标记和口服药物治疗的增加似乎在引起和预测这些患者的骨不连中起重要作用。

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