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首页> 外文期刊>Acute and critical care. >The Role of Transbronchial Lung Biopsy in Diagnosing Pulmonary Mucormycosis in a Critical Care Unit
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The Role of Transbronchial Lung Biopsy in Diagnosing Pulmonary Mucormycosis in a Critical Care Unit

机译：重症监护病房经支气管肺活检在诊断肺毛霉菌病中的作用

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Background Pulmonary mucormycosis (PM) is an emerging infectious disease and a life-threatening infection with high mortality. The clinical outcomes of PM have not improved significantly over the last decade because early diagnosis of PM is difficult and antifungal agents show limited activity. We evaluated the clinical manifestations of PM in a Korean tertiary hospital and identified the role of transbronchial lung biopsy (TBLB) in diagnosing PM in patients admitted to an intensive care unit. Methods The medical records of adult patients (aged 16 years and older) who met the criteria for proven or probable PM in a Korean tertiary hospital were retrospectively reviewed from January 2003 to December 2013. The clinical features, computed tomographic findings, diagnostic methods, treatment, and outcomes in patients with PM were evaluated. Results Of the nine patients, four were male. The median age was 64 years (range, 12 to 73 years). PM was proven and probable in seven and two cases, respectively. Computed tomography findings of PM were unilateral involvement in eight cases (89%), consolidation in eight (89%), ground glass opacity in four (44%), and reverse halo sign in one (11%). Six of nine cases (67%) were diagnosed as PM from TBLB via portable bronchoscopy. There were no complications after TBLB. Mortality rate was 56% (five of nine cases). Conclusions TBLB can be an easy and useful technique for diagnosing PM in the intensive care unit.
机译：背景技术肺毛霉菌病（PM）是一种新兴的传染病，是一种威胁生命的感染，死亡率高。在过去的十年中，PM的临床结果并未显着改善，因为很难对PM进行早期诊断并且抗真菌药物的活性有限。我们评估了韩国一家三级医院的PM的临床表现，并确定了经支气管肺活检（TBLB）在重症监护病房的患者诊断PM中的作用。方法回顾性分析2003年1月至2013年12月在韩国三级医院中确诊或可能患有PM的成年患者（16岁及以上）的病历。其临床特征，CT表现，诊断方法，治疗方法，并评估了PM患者的结局。结果9例患者中，男性4例。中位年龄为64岁（范围为12至73岁）。 PM分别在7例和2例中被证明是有可能的。 PM的计算机断层扫描检查结果为单侧受累8例（89％），巩固8例（89％），毛玻璃不透明4例（44％）和反晕征1例（11％）。 9例中有6例（67％）通过便携式支气管镜检查被TBLB诊断为PM。 TBLB后无并发症。死亡率为56％（9例中的5例）。结论TBLB可作为重症监护病房诊断PM的简便实用技术。

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