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首页> 外文期刊>Advances in Bioscience and Clinical Medicine >The Therapeutic Potential of Resveratrol in Gliomas
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The Therapeutic Potential of Resveratrol in Gliomas

机译：白藜芦醇在胶质瘤中的治疗潜力

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Resveratrol (RSV) is found in most human foods especially fruits such as grapes, peanuts, strawberry, blueberry, cranberry, mulberry, lingberry, sparkleberry, bilberry and in flowers as well as leaves like butterfly orchid tree, eucalyptus, spruce, lily, gnetum and so many others. Functionally, RSV has the propensity to safeguard DNA as well as the induction of DNA repair. RSV is precipitously metabolized in the liver via phase-II detoxification enzymes leading to its principal urine excretion. RSV steered growth inhibition, induction of apoptosis and G0/G1-phase cell cycle arrest in an experiment involving glioma cells. RVS can block the triggering of signal transducer and activator of transcription (STAT3) signaling of glioma cells. RSV subdues STAT3 signaling via the inhibition of SRC or Janus kinase (JAK2) induction, thereby inducing growth inhibitory and apoptotic properties. RSV explicitly blocks both COX-1 and COX-2 in-vitro. In the cancer inflammatory milieu, the blockade effects of RSV on NF-κB could also lead to the blockade of TNF-α resulting in inhibition of cancer advancement as well as metastasis. Individually, RSV has proven to very potent in glioma cells. It is able to down-regulate glioma angiogenesis as well as metastasis. In combination with other agents, RVS augment its potency in glioma. RVS is able to cross the blood brain barrier (BBB) via gap junctions making it very efficient central nervous system medication. RVS after oral administration peaks in the blood stream after one hour meaning it acts very fast. This review focuses on the neuropharmacological role of RVS in glioma.
机译：白藜芦醇（RSV）存在于大多数人类食品中，尤其是水果中，例如葡萄，花生，草莓，蓝莓，酸果蔓，桑树，越橘，越橘，越橘和花朵以及诸如蝴蝶兰花，桉树，云杉，百合，金刚花的叶子中等等。从功能上讲，RSV具有保护DNA和诱导DNA修复的倾向。 RSV通过II期解毒酶在肝脏中急剧代谢，导致其主要尿液排泄。在涉及神经胶质瘤细胞的实验中，RSV指导了生长抑制，凋亡诱导和G0 / G1期细胞周期停滞。 RVS可以阻止神经胶质瘤细胞的信号转导和转录激活（STAT3）信号的触发。 RSV通过抑制SRC或Janus激酶（JAK2）的诱导来抑制STAT3信号传导，从而诱导生长抑制和凋亡特性。 RSV明确地在体外阻止COX-1和COX-2。在癌症炎症环境中，RSV对NF-κB的阻滞作用也可能导致TNF-α的阻滞，从而抑制了癌症的进展以及转移。单独地，RSV已被证明在神经胶质瘤细胞中非常有效。它能够下调神经胶质瘤的血管生成以及转移。结合其他药物，RVS可增强其在神经胶质瘤中的作用。 RVS能够通过间隙连接点穿越血脑屏障（BBB），使其成为非常有效的中枢神经系统药物。口服后RVS在一个小时后在血流中达到峰值，这意味着它的作用非常快。这篇综述集中在RVS在神经胶质瘤中的神经药理作用。

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