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The S100B Protein Could Be Used as Adjuvant Diagnostic Tool in Acute Ischemic Stroke

机译：S100B蛋白可作为急性缺血性卒中的辅助诊断工具

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BACKGROUND: In the emergency department, the diagnosis of ischemic stroke is difficult because the diagnostic modalities are limited to non-contrast brain CT and neurologic examination. Serum S100B protein, a bio-marker for ischemic stroke, is needed as an additional diagnostic aid in acute ischemic stroke. METHODS: We retrospectively reviewed 50 patients diagnosed with ischemic stroke between August 2007 and December 2008 by brain MRI after brain CT and serum S100B measurement in the emergency department. The serum levels of S100B protein were analyzed and the diagnostic sensitivity of non-contrast brain CT combined with abnormal elevation of S100B protein was compared with that of non-contrast brain CT alone. RESULTS: The overall sensitivity of non-contrast brain CT in the diagnosis of ischemia was 54%. S100B protein in early ischemia had a sensitivity of 58%. However, combining non-contrast brain CT and S100B increased the sensitivity to 74%. CONCLUSIONS: A biomarker-based diagnostic test would not replace the necessity for CT or other early imaging studies, and before contemplating any reperfusion strategy, neuro-imaging must be performed to rule out intracranial hemorrhage. However, S100B protein, a serum bio-marker, is able to help emergency physicians evaluate patients with suspected ischemic stroke and decide on treatment.
机译：背景：在急诊科，缺血性中风的诊断很困难，因为其诊断方式仅限于非对比脑CT和神经系统检查。血清S100B蛋白是缺血性中风的生物标志物，需要作为急性缺血性中风的附加诊断辅助手段。方法：我们回顾性分析了急诊科在2007年8月至2008年12月之间通过脑MRI进行脑MRI和血清S100B测定后诊断为缺血性中风的50例患者。分析了血清S100B蛋白的水平，并比较了非对比脑CT与S100B蛋白异常升高与单独的非对比脑CT的诊断敏感性。结果：对比脑CT在缺血诊断中的总体敏感性为54％。 S100B蛋白在早期缺血中的敏感性为58％。但是，将非对比脑CT和S100B结合使用可使敏感性提高到74％。结论：基于生物标志物的诊断测试不能代替CT或其他早期影像学研究的必要性，并且在考虑任何再灌注策略之前，必须进行神经影像学检查以排除颅内出血。但是，S100B蛋白是一种血清生物标志物，能够帮助急诊医师评估可疑的缺血性中风患者并决定治疗方案。

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