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Application of carbon monoxide for treatment of acute kidney injury

机译：一氧化碳在急性肾损伤治疗中的应用

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Acute kidney injury in critically ill patients is common and associated with a substantial increase in morbidity and mortality. Even with aggressive medical care and renal replacement therapy, acute kidney injury remains a significant health care concern. Recent published reports offer new strategies for the prevention and amelioration of acute kidney injury using carbon monoxide. Although considered a toxic environmental gas, carbon monoxide has recently aroused scientific and clinical interest, as its beneficial effects and mechanisms of action have been substantially defined in variousin vitro andin vivo experiments. The exogenous application of carbon monoxide can confer cytoprotection by modulating intracellular signaling pathways through its anti‐inflammatory, anti‐apoptotic, vasodilative, antithrombotic and antiproliferative properties. Thus, evidence is accumulating to support the notion of carbon monoxide treatment for acute kidney disease. In this review, we focus on the extensively analyzed advantageous value of treatment with inhaled/soluble carbon monoxide in the context of kidney injury. Mechanisms such as signaling pathways, as well as an expanded view regarding toxicity and side‐effects, are described broadly. In addition, we discuss the clinical applicability of carbon monoxide as a promising therapeutic strategy for the treatment of patients with acute kidney disease based on translating basic experimental findings into clinical application.
机译：重症患者的急性肾损伤很常见，并且与发病率和死亡率的大幅增加有关。即使采用积极的医疗护理和肾脏替代疗法，急性肾损伤仍然是重要的医疗保健问题。最近发表的报告提供了使用一氧化碳预防和改善急性肾损伤的新策略。尽管一氧化碳被认为是有毒的环境气体，但近来引起了科学和临床兴趣，因为其有益作用和作用机理已在各种体外和体内实验中得到实质性定义。一氧化碳的外源应用可通过其抗炎，抗凋亡，血管舒张，抗血栓形成和抗增殖特性来调节细胞内信号通路，从而赋予细胞保护作用。因此，越来越多的证据支持一氧化碳治疗急性肾病的概念。在这篇综述中，我们专注于广泛分析的吸入/可溶性一氧化碳治疗肾脏损伤的有利价值。广泛描述了信号传导途径等机制，以及有关毒性和副作用的扩展视图。此外，我们将基础实验结果转化为临床应用，讨论了一氧化碳作为一种有前景的治疗急性肾病患者的治疗策略的临床适用性。

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