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首页> 外文期刊>Advances in Microbiology >Urinary Tract Infection among Pregnant Women at Pumwani Maternity Hospital, Nairobi, Kenya: Bacterial Etiologic Agents, Antimicrobial Susceptibility Profiles and Associated Risk Factors
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Urinary Tract Infection among Pregnant Women at Pumwani Maternity Hospital, Nairobi, Kenya: Bacterial Etiologic Agents, Antimicrobial Susceptibility Profiles and Associated Risk Factors

机译：肯尼亚内罗毕，Pumwani妇产科医院孕妇的尿路感染：细菌病因，抗菌药物敏感性和相关危险因素

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Urinary Tract Infections (UTIs) during pregnancy are among the most common infections worldwide and can lead to poor perinatal and maternal outcomes. This study determined the prevalence of UTIs during pregnancy, associated risk factors and antimicrobial susceptibility profiles of associated bacterial pathogens. A cross-sectional study was conducted among 210 pregnant women attending antenatal clinic at Pumwani Maternity hospital. Their social-demographic profiles were obtained using a structured questionnaire. Cultures were done from midstream urine and antimicrobial susceptibility testing determined using the disc diffusion test. The overall prevalence of UTI was 15.7% regardless of the women’s age, parity and stage of gestation. Prevalence of asymptomatic and symptomatic bacteriuria was 4.3% and 11.4% respectively. Material of undergarment and frequency of changing the undergarments were found to contribute significantly to the acquisition of UTI (P < 0.05). E. coli was the most predominant UTI organism at (44.5%) followed by K. pneumoniae (21.2%) and S. aureus (15.1%). Almost a half (over 49%) of all Gram-negative organisms showed resistance prevalence against third generation cephalosporins, fluoroquinolones, Sulfamethoxazole-Trimethoprim, Cefoxitin, Nitrofurantoin and Amoxicillin-clavulanic acid. Gram-positive strains were susceptible to Amoxicillin-clavulanic acid, Nitrofurantoin, Linezolid and Ofloxacin. The prevalence of multi-drug resistance (MDR) in all study isolates was 96%. Our data suggest a serious resistance trend among UTI strains and more should be done to slow down this trend. Pregnant women should be screened by urine culture and treatment be guided by the antimicrobial susceptibility data.
机译：怀孕期间的尿路感染（UTI）是世界上最常见的感染之一，可能导致围产期和产妇预后不良。这项研究确定了妊娠期尿路感染的患病率，相关的危险因素和相关细菌病原体的抗菌药敏性。在Pumwani妇产医院接受产前检查的210名孕妇中进行了横断面研究。他们的社会人口统计资料是使用结构化问卷获得的。从中游尿液进行培养，并使用椎间盘扩散试验确定抗菌药敏试验。无论女性的年龄，胎次和妊娠阶段如何，UTI的总体患病率为15.7％。无症状菌尿和有症状菌尿的患病率分别为4.3％和11.4％。发现内衣的材料和更换内衣的频率显着促进了尿路感染的获得（P <0.05）。大肠杆菌是最主要的UTI生物，占44.5％，其次是肺炎克雷伯菌（21.2％）和金黄色葡萄球菌（15.1％）。所有革兰氏阴性菌中近一半（超过49％）显示出对第三代头孢菌素，氟喹诺酮类，磺胺甲恶唑-甲氧苄啶，头孢西丁，硝基呋喃妥因和阿莫西林-克拉维酸的抗药性。革兰氏阳性菌株对阿莫西林-克拉维酸，硝基呋喃妥因，利奈唑胺和氧氟沙星敏感。在所有研究菌株中，多重耐药性（MDR）的患病率为96％。我们的数据表明，UTI菌株之间存在严重的耐药性趋势，应采取更多措施来减缓这种趋势。孕妇应通过尿液培养进行筛查，并在抗菌药敏感性数据的指导下进行治疗。

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